Jimmy Garoppolo - George Kittle - Tyler Lockett
In this game, I expect Garoppolo to have to throw a lot going up against the elite Seattle offense as 3-point underdogs without their top RBs Raheem Mostert, Jeff Wilson and potentially Tevin Coleman.
Kyle Shanahan is a smart coach and obviously the weakness of Seattle is their historically bad pass defense, which has given up by far the most yards in the league, including almost 400 to Cam Newton, who hasn’t been able to do anything since. Seattle has been hemorrhaging fantasy production to QBs all season, allowing QB1 performances in 5 of 6 games, including 4 top-3 results at the position.
Garoppolo should be to get the 300-yard bonus. And if he throws a couple of TDs, he will easily achieve value at just $5,400 on DraftKings this week.
Kittle is an easy stack option with Garoppolo as Deebo Samuel has been ruled out due to injury. Kittle easily leads the 49ers in targets with Garoppolo at the helm. He’s commanded targets on 34% of his routes against zone coverage — and Seattle plays zone at the NFL’s second highest rate, which should boost Kittle’s projection even more.
Tyler Lockett could certainly be used as the run-back option as he leads the Seahawks in targets, catches, yards and TDs coming off a monster 15-200-3 against the Cardinals.
Lockett has 14 more targets than teammate D.K. Metcalf and appears to have a higher ceiling with 2 slate-breaking performances already this season.