49ers HC Kyle Shanhan labeled WR Brandon Aiyuk "week to week" with a "mild strain" in his left hamstring. It's the 1st update we've gotten on the rookie since he went down in Sunday's practice. Aiyuk was off to a hot start in camp and seemed destined to play a big role right out of the gate. This injury might impact that plan. We'll see when Aiyuk is able to get back on the field.

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49ers WR Brandon Aiyuk suffered a high-ankle sprain in Saturday's win over the Cardinals and will miss the finale vs. the Seahawks. It ends an impressive rookie campaign that saw Aiyuk average 6.6 catches, 83 yards and .6 TDs over his final 7 games. Kendrick Bourne and Richie James will close out the season as San Francisco's top 2 WRs.

49ers WR Brandon Aiyuk has been activated from the COVID list. That puts him in line to return for Monday night's game against the Bills. San Francisco has had Aiyuk and Deebo Samuel together for only 4 games this season. Samuel has out-targeted Aiyuk 22 to 21 in those contests.

2:11pm EST 11/29/20

49ers WR Brandon Aiyuk (COVID) is out for today’s game against the Rams. Deebo Samuel, Richie James and Kendrick Bourne should operate as San Francisco’s top 3 WRs.

As of Friday evening, 49ers WR Brandon Aiyuk remains on the COVID list. HC Kyle Shananah said he hasn't heard any updates on Aiyuk's chances of getting cleared in time for Sunday's game against the Rams. San Francisco promoted WR Jordan Matthews from the practice squad, so the team is obviously preparing to be without Aiyuk. He should be on fantasy benches for now.

49ers WR Brandon Aiyuk has been placed back on the COVID list. San Francisco has a Week 11 bye, but we'll see if the rookie is cleared in time for next week's game vs. the Rams.

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