Comments: Guerendo sustained the injury while lifting weights. He was placed on the PUP list and missed all of training camp. UPDATE: Guerendo was placed on the reserve/PUP list and will miss the first four weeks of the 2026 season.
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| Date | League | Injury | Level | Games Missed | Details |
|---|---|---|---|---|---|
| Apr 30, 2026 | NFL | Chest Pectoral Tear | Grade 3 | — | Guerendo sustained the injury while lifting weights. He was placed on the PUP list and missed all of training camp. UPDATE: Guerendo was placed on the reserve/PUP list and will miss the first four weeks of the 2026 season. |
| Aug 2, 2025 | NFL | Shoulder | — | — | Guerendo suffered an apparent shoulder injury during special-teams drills. |
| Jan 5, 2025 | NFL | Knee MCL Pull | Grade 1 | — | Guerendo suffered knee and ankle injuries in the regular-season finale loss to the Cardinals. |
| Dec 18, 2024 | NFL | Thigh Hamstring Sprain/Pull | Grade 1 | 1 | Guerendo was ruled out for Week 16's game at Miami due to a hamstring injury. |
| Dec 8, 2024 | NFL | Pedal Foot Sprain | — | — | Guerendo suffered a foot injury in the fourth quarter of Week 14's game vs. the Bears. |
| Jul 24, 2024 | NFL | Thigh Hamstring Sprain/Pull | Grade 1 | — | Guerendo injured his hamstring during training camp practice but recovered in time for the preseason game against Las Vegas. |
| Oct 2, 2021 | NFL | Pedal Ankle Ligament | Grade 3 | 8 | Guerendo suffered a season-ending ankle injury against Michigan. He was out for the spring |
49ers’ second-string RB Isaac Guerendo returned to practice on Tuesday, according to Nick Wagoner of ESPN. Guerendo had been sidelined for multiple weeks with a shoulder injury.
San Francisco rookie RB Jordan James suffered a broken finger and will miss a few weeks, according to Matt Barrows of The Athletic.
49ers RB Isaac Guerendo is expected to miss "a few weeks" with a shoulder injury suffered in training camp, HC Kyle Shanahan said Monday. We're about a month away from the start of the regular season, so it sounds like Guerendo has a chance to be ready for Week 1. But we'll keep tabs on his status.
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