The Seahawks have ruled CB Riq Woolen (ankle) and DT Byron Murphy (hamstring) out for Thursday night's game against the 49ers. Edge Uchenna Nwosu (thigh) is also out and expected to land on IR ahead of the game. Additionally, Seattle lists Edge Derick Hall (foot), Edge Boye Mafe (knee), and S Julian Love (hamstring) as questionable vs. San Francisco. Love played through the same issue in Week 5, missing just one of 71 snaps. But HC Mike Macdonald calls him a game-time decision on the short week. Macdonald said Wednesday he's "confident" Hall and Mafe will play. Each practiced in full Wednesday.
Giants RB Devin Singletary (groin) got in a limited practice on Wednesday. HC Brian Daboll said afterward that Singletary is "trending in the right direction." We're expecting him back for Sunday night's game vs. the Bengals, although it's possible that Singletary cedes more work to RB Tyrone Tracy.
Giants WR Malik Nabers (concussion) remained sidelined for Wednesday's practice. It's surprising and concerning that he's still out 13 days after his concussion. HC Brian Daboll said that Nabers is "doing better" and "day-to-day." But his availability for Sunday night's game vs. the Bengals is in jeopardy. Nabers likely needs to practice tomorrow to have a chance to be cleared for that one.
Bengals RB Zack Moss (foot) did not practice on Wednesday. He appeared to get banged up late in last week's loss to the Ravens, and his status for Sunday night's game vs. the Giants is now uncertain. Moss' absence would turn RB Chase Brown into a must-start. We'll see if Moss gets back on the field tomorrow.
Panthers WR Xavier Legette (shoulder) was a full-go in Wednesday's practice. He was knocked out early in last weekend's game but is on track to play vs. the Falcons this weekend. Legette should step back in as Carolina's No. 2 WR and is a WR4 consideration for fantasy squads.
Raiders RB Zamir White (groin) did not practice on Wednesday. With White out last week, RB Alexander Mattison played 57% of Vegas' offensive snaps and handled 15 carries with three targets. Expect a similar workload this weekend if White remains out, but a matchup against the Steelers' 11th-ranked RB defense would leave Mattison as an unexciting RB3.
Broncos RB Audric Estime (ankle) has been activated from IR and put in a full practice on Wednesday. It looks like he'll be available for this weekend's game vs. the Chargers. Estime lost a fumble and then hurt his ankle in the opener, so we wouldn't expect him to have a significant role in the short term. We'll see if the rookie can work his way into Denver's backfield rotation.
Chargers RB Gus Edwards (ankle) did not practice on Wednesday. It could be an early-week rest day for the veteran, but the Chargers are coming off their bye week. We'll see if Edwards gets back on the field tomorrow. If he misses Sunday's game vs. the Broncos, we could see rookie RB Kimani Vidal make his regular-season debut.
Titans QB Will Levis (shoulder) put in a full practice on Wednesday. That has him on track to start this weekend's game vs. the Colts. The biggest fantasy impact there? The Colts DST is a nice Week 6 option. Levis has six INTs and three fumbles in a little more than three games this season.
Colts RB Jonathan Taylor (ankle) remained sidelined for Wednesday's practice. "He’s working through it, he’s looking good," HC Shane Steichen said of JT. "We’ll see how the week goes for him, hopeful that he’ll be out there." Fantasy owners should not be counting on Taylor in Week 6 fantasy lineups. RB Trey Sermon (collarbone) also missed Wednesday's practice. No word on his status for Sunday's game vs. the Titans. If Taylor and Sermon are out, RB Tyler Goodson would be left as Indianapolis' starter.
Colts QB Anthony Richardson (oblique) remained limited in Wednesday's practice. He was limited all last week before missing the Jaguars game. Richardson's status for this weekend's game vs. the Titans remains uncertain. We'll track his progress over the next few days.
Eagles WRs A.J. Brown (hamstring) and DeVonta Smith (hamstring) were full participants in Wednesday's practice. They're both on track to return and play their usual roles vs. the Browns this weekend. Get them back into fantasy lineups.
Browns TE David Njoku (knee, ankle) did not practice on Wednesday. He returned from his high-ankle sprain last week and subsequently suffered a knee injury. Njoku doesn't seem particularly likely to play vs. the Eagles this weekend, but we'll track his status over the next few days.
Saints HC Dennis Allen said Wednesday that QB Spencer Rattler will start this weekend's game vs. the Bucs. The fifth-round rookie boasts exciting arm talent but completed just 53% of his passes at 5.3 yards per attempt this preseason. He's not a Week 6 fantasy option and is a downgrade for New Orleans' pass catchers. Allen also said Wednesday that QB Derek Carr (oblique) is "week to week" but won't go on IR.
Saints WR Rashid Shaheed (hip) did not practice on Wednesday. This could just be a rest day coming off the Monday nighter in Kansas City, but we'll update Shaheed's status again tomorrow. Assuming he plays vs. the Bucs this weekend, he'll be a shaky WR3 with QB Spencer Rattler at the controls.
Saints RB Alvin Kamara (hip, hand) did not practice on Wednesday. He seemed to make it out of Monday night's game vs. the Chiefs ok, so this is likely more of a rest day. We'll see if Kamara gets back on the field tomorrow.
Patriots RB Rhamondre Stevenson missed Wednesday's practice with a foot injury. He got banged up late in last week's loss to the Dolphins but said afterward that he expected to be fine for Week 6. We'll see if he gets back on the field tomorrow. Stevenson's absence against the Texans this weekend would mean a heavy workload for RB Antonio Gibson.
Texans RB Joe Mixon (ankle) remained sidelined for Wednesday's practice. HC Demeco Ryans labeled him "week to week" on Monday, so fantasy owners should not be expecting Mixon back for this weekend's game vs. the Patriots. RB Dameon Pierce (hamstring) was limited on Wednesday and is on track to return for Sunday's game. In that case, you should avoid Houston's backfield in Week 6 fantasy lineups.
Packers WR Christian Watson (ankle) returned to a limited practice on Wednesday. He seemingly has a shot to play vs. the Cardinals this weekend. Watson would be tough to trust in fantasy lineups in his first game back from what was reportedly a high-ankle sprain. But his return would take WR Dontayvion Wicks out of fantasy-lineup consideration.
Commanders RB Brian Robinson (knee) did not practice on Wednesday. He played through this injury last week, although he didn't record a touch in the second half. HC Dan Quinn said he was protecting his player in game that was never in question in the second half. Robinson figures to play vs. the Ravens on Sunday, but he likely won't be at 100%.
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