Isaac Guerendo Fantasy Overview

The 49ers might be preparing to hand a high-value job to a player with little NFL experience. According to The Athletic's Matt Barrows, second-year RB Jordan James "appears to be the frontrunner to be the top backup this season." San Francisco drafted James in the fifth round last year, but an injury-plagued summer kept him from competing for a regular-season roster spot. James didn't touch the ball until the playoff loss to Seattle (six carries and one catch at the end of a blowout).

Niners RB Christian McCaffrey might have been questionable entering the weekend, but you wouldn't have known it by the way the team used him in the victory over Seattle. McCaffrey rushed 22 times and caught nine of 10 targets Sunday. He led his nearest teammates by three targets and five catches. That workload helped prop up an inefficient day on the ground, where McCaffrey managed a mere 3.1 yards per carry. His 73 receiving yards marked a solid 8.1-yard average. McCaffrey wound up with the third-best PPR score among RBs for the week (pending Monday night) even without scoring a TD.

49ers RB Christian McCaffrey (calf) is active for today’s game vs. the Seahawks. He popped up on Thursday’s injury report as limited and officially did not practice on Friday. McCaffrey went through an extensive warmup on Friday, though, and didn’t sound concerned about his status afterward. Fox Sports’ Jay Glazer reported this morning that scans on McCaffrey’s calf came back “completely clean.” There’s still some additional risk here, but CMC belongs in Week 1 fantasy lineups. RB Jordan James (finger) is inactive today, leaving RBs Brian Robinson and Isaac Guerendo behind McCaffrey.

49ers RB Christian McCaffrey (calf) is listed as questionable for this weekend's game vs. the Seahawks. He was added to the injury report and limited in practice on Thursday and officially did not practice on Friday. McCaffrey was on the field going through warmups at the start of Friday's practice, though, and looked reasonably healthy. We'll surely get multiple updates on McCaffrey between now and kickoff on Sunday. Hopefully he's not a game-time decision, though, because 49ers-Seahawks doesn't kick off until 4:05 pm ET. McCaffrey's absence would leave Brian Robinson as San Francisco's lead back, although it's unclear exactly how big a role he'd be ready for after joining the team on August 22. RB Isaac Guerendo will also be available for the 'Niners, but RB Jordan James (finger) is doubtful.