49ers RB Christian McCaffrey (back) is active for today’s game vs. the Titans. He was added to the injury report as questionable on Saturday, but ESPN’s Adam Schefter reported a short time later that McCaffrey would be “good to go” for this one. We haven’t heard anything about his snaps or touches being limited today. McCaffrey remains a must-start.

49ers RB Christian McCaffrey has been added to the injury report with a back issue and is now questionable for Sunday's game vs. the Titans. We don't have any other details at this point. McCaffrey has no noted history of back trouble. We'll of course keep you updated on his status. But RB Brian Robinson would turn into a strong fantasy play if McCaffrey misses tomorrow's game and needs to be rostered in all fantasy leagues.

49ers QB Brock Purdy (toe) and WRs Ricky Pearsall (knee) and Jauan Jennings (ankle, ribs) have all been ruled out for Thursday night's game against the Rams. It doesn't sound like any of their injuries are serious, but the short week did them no favors. We'll see if they can make it back for Week 6. QB Mac Jones makes another start vs. the Rams this week. He played well in Week 2 and 3 starts, completing 66% of his passes at 7.0 yards per attempt with 4 TDs vs. 1 INT. He'll be working with a rag tag group of pass catchers on Thursday night, though. The WR corps figures to be led by Kendrick Bourne, Demarcus Robinson, and Skyy Moore, while Jake Tonges again leads the TE room. We'd try not to mess with any of these guys in Week 5 fantasy lineups. RB Christian McCaffrey will be very busy yet again.

49ers RB Christian McCaffrey (calf) is active for today’s game vs. the Seahawks. He popped up on Thursday’s injury report as limited and officially did not practice on Friday. McCaffrey went through an extensive warmup on Friday, though, and didn’t sound concerned about his status afterward. Fox Sports’ Jay Glazer reported this morning that scans on McCaffrey’s calf came back “completely clean.” There’s still some additional risk here, but CMC belongs in Week 1 fantasy lineups. RB Jordan James (finger) is inactive today, leaving RBs Brian Robinson and Isaac Guerendo behind McCaffrey.

49ers RB Christian McCaffrey (calf) is listed as questionable for this weekend's game vs. the Seahawks. He was added to the injury report and limited in practice on Thursday and officially did not practice on Friday. McCaffrey was on the field going through warmups at the start of Friday's practice, though, and looked reasonably healthy. We'll surely get multiple updates on McCaffrey between now and kickoff on Sunday. Hopefully he's not a game-time decision, though, because 49ers-Seahawks doesn't kick off until 4:05 pm ET. McCaffrey's absence would leave Brian Robinson as San Francisco's lead back, although it's unclear exactly how big a role he'd be ready for after joining the team on August 22. RB Isaac Guerendo will also be available for the 'Niners, but RB Jordan James (finger) is doubtful.

"I do not get the sense based on the conversations I've had so far that there are alarm bells going off about Christian McCaffrey at this point," NFL Network's Tom Pelissero said Friday morning. It's just about the most positive update we could have hoped for after McCaffrey was added to Thursday's injury report with a calf. McCaffrey was not in the locker room after Thursday's workout and did not do his usual media session, according to ESPN's Nick Wagoner. We'll get another update on McCaffrey this afternoon when the 49ers release their final Week 1 injury report.

49ers RB Christian McCaffrey was added to the injury report and limited in practice on Thursday with a calf. Not what we wanted to see after last year's Achilles fiasco. We don't have any other details on McCaffrey's situation right now -- how serious the calf issue is or whether it's related to last year's Achilles trouble. We'll update his status as soon as we learn more. No. 2 RB Brian Robinson Jr. should be rostered in all fantasy leagues, and even No. 3 RB Isaac Guerendo is worth stashing for now in many spots.

49ers’ second-string RB Isaac Guerendo returned to practice on Tuesday, according to Nick Wagoner of ESPN. Guerendo had been sidelined for multiple weeks with a shoulder injury.

49ers RB Isaac Guerendo is expected to miss "a few weeks" with a shoulder injury suffered in training camp, HC Kyle Shanahan said Monday. We're about a month away from the start of the regular season, so it sounds like Guerendo has a chance to be ready for Week 1. But we'll keep tabs on his status.

According to ESPN’s Nick Wagoner, the 49ers are still unsure when WR Brandon Aiyuk will return. Aiyuk suffered a multi-ligament knee injury back in Week 7 of the 2024 campaign. With WR Deebo Samuel now in Washington, there are plenty of targets available in San Francisco.

After an injury-wrecked 2024 season, 49ers RB Christian McCaffrey has enjoyed a healthy offseason. "I feel great," McCaffrey said this week. "I think this offseason I spent a lot of time kind of building back a base starting from scratch, so a lot of it was rehab and wanted to put myself in a position where I didn't miss a day of OTAs and I could practice and play football again, be healthy and not miss a day, and I did that."

It doesn't sound like the 49ers plan on scaling back RB Christian McCaffrey's volume this season, despite an injury-wrecked 2024. "We’re gonna do everything we can to get him the ball as much as we can," OC Klay Kubiak said recently. Kubiak added that McCaffrey is "doing great" and "looks awesome" coming off his Achilles and knee injuries.

49ers RB Christian McCaffrey is participating in the team's offseason program this week with no restrictions. McCaffrey struggled through an injury-riddled 2024 season, missing the first eight games with Achilles tendonitis and the last five with a right knee (PCL) injury. Neither ailment looks like a concern heading into the 2025 campaign.

49ers RB Christian McCaffrey told reporters Monday that he's "definitely close" to 100% recovered from his knee injury. He suffered a right PCL injury in Week 13 that ended his season. McCaffrey believes he could have played if San Francisco had made the playoffs, though, and expects to be ready for OTAs. He also said that his Achilles tendonitis has "100% calmed down" and won't be an issue next season.

Niners HC Kyle Shanahan confirmed Monday that RB Christian McCaffrey will miss at least the rest of the regular season with the PCL injury in his right knee. He also revealed that RB Jordan Mason will head to IR with a high-ankle sprain.