49ers WR Deebo Samuel (ankle, knee) is out for Thursday night's game vs. the Seahawks. It sounds like he'll be back in either Week 17 or 18. Samuel's absence elevates Jauan Jennings to the #2 WR role and frees up targets for RB Christian McCaffrey, WR Brandon Aiyuk and TE George Kittle.

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49ers WR Deebo Samuel suffered an MCL sprain and an ankle sprain in Sunday's win over the Bucs, the team announced on Monday. Samuel is expected to return at some point in the regular season, but we'd prepare for him to miss multiple games. We'll hopefully get a more concrete timeline for Samuel's return before you need to decide whether to release him from fantasy rosters. Jauan Jennings will take over as San Francisco's #2 WR with Samuel out but is unlikely to be a reliable fantasy play at this point in the season. RB Christian McCaffrey, WR Brandon Aiyuk and TE George Kittle are all candidates to pick up extra targets with Samuel out.

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WR Jauan Jennings led the 49ers with 6 catches in Sunday's win over the Saints, taking them for 49 yards and the team's lone TD. Jennings' 7 targets tied Deebo Samuel for 2nd on the team, trailing only WR Brandon Aiyuk. Samuel caught 3 balls for 43 yards, adding 2 carries for no gain. Aiyuk caught 5 passes for 65 yards. TE George Kittle contributed 3 receptions for 26 yards on 4 targets.

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