Niners WR Brandon Aiyuk caught all 6 of his targets in Sunday's win over the Rams. He tallied 81 yards and caught a TD throw from RB Christian McCaffrey. San Francisco went without WR Deebo Samuel. McCaffrey led the team in targets and receptions, with TE George Kittle (5 targets) following McCaffrey and Aiyuk. QB Jimmy Garoppolo completed 21 of 25 passes (84%) for 235 yards and TDs to McCaffrey and Kittle.

49ers WR Brandon Aiyuk (shoulder) is officially inactive for tonight's game vs. the Giants. He seemed relatively close to playing tonight, so we're tentatively expecting him back for Week 4. Aiyuk's absence should make San Francisco's offense even more concentrated, with RB Christian McCaffrey, WR Deebo Samuel, and TE George Kittle dominating touches.

The 49ers have downgraded WR Brandon Aiyuk to out for tonight's game against the Giants because of his shoulder injury. That should make Jauan Jennings the No. 2 WR for the upside matchup. Aiyuk (14) and Deebo Samuel (16) have accounted for 88.2% of WR targets for San Francisco through two weeks, with Jennings claiming the only other four. Jennings posted three games of 4+ receptions last year, though none came with Brock Purdy behind center. Jennings makes for a nice play in Thursday night DFS showdowns. He's too much of a longshot for most season-long redraft formats, though. Seventh-round rookie Ronnie Bell has been the No. 4 WR in playing time so far and matched Jennings in snaps in Week 2. He has yet to see a target, though.

The 49ers list WR Brandon Aiyuk (shoulder) as questionable for Thursday night's game against the Giants. ESPN's Nick Wagoner reports that HC Kyle Shanahan "indicated" Aiyuk will be a game-time decision. Fortunately, it's the first game of the week. So we'll know more before you're setting your Week 3 lineups.

49ers WR Brandon Aiyuk (shoulder) will be a game-time decision for Thursday night's meeting with the Giants, HC Kyle Shanahan said Tuesday. Aiyuk was limited in Tuesday's practice. We'll continue to look for updates on his status, but it seems like he'll come with elevated risk in Week 3 fantasy lineups if he does suit up on Thursday night.

A CT scan on 49ers WR Brandon Aiyuk's clavicle came back clean, according to The Santa Rosa Press Democrat's Jack Hammer. "His ability to play Thursday night will be all about pain tolerance," Hammer adds. We'll keep an eye on Aiyuk's status and will get San Francisco's inactives around 7 pm ET on Thursday.