Bills RB LeSean McCoy (thumb) is listed as questionable for Sunday's game against the Jaguars. He was limited in practice all week and was still sporting a "huge wrap" on that injured thumb on Friday, per insider Joe Buscaglia. McCoy is expected to play vs. Jacksonville, but the thumb issue certainly adds some risk. For what it’s worth, HC Rex Ryan said Friday that McCoy should be “ready to get the majority of the reps.” RB Mike Gillislee (hamstring) is out for Week 12, leaving Reggie Bush and Jonathan Williams as McCoy's backups.

The Bills will use a RB rotation vs. New England today and ride the "hot hand," according to ESPN's Adam Schefter. Mike Gillislee still figures to get the 1st crack and remains the preferred fantasy play. But he could lose touches to Reggie Bush and/or Jonathan Williams. The Patriots rank 8th in fantasy points allowed to RBs and are giving up just 3.6 yards per carry.

The Bills have listed RB LeSean McCoy (hamstring) as doubtful for Sunday's game against the Patriots. He didn't practice all week, and HC Rex Ryan essentially confirmed on Friday that McCoy won't play. (In a very Rex-ish way.) RB Mike Gillislee figures to operate as Buffalo's lead back, with Reggie Bush and Jonathan Williams backing him up. New England ranks 8th in fantasy points allowed to RBs, but volume puts Gillislee on the RB2 map.

Reggie Bush is "considered the favorite" for the Bills' #2 RB job, according to ESPN's Mike Rodak. Bush was the 2nd RB into Saturday's preseason game, losing a yard on his 1 carry. RB Mike Gillislee later suffered a concussion. Buffalo's run-heavy offense figures to grant Bush a handful of carries per game, and we'll see how much passing-down work he steals from LeSean McCoy. But Bush is 31 now and has been ineffective the past 2 seasons. We're not very interested in him in fantasy drafts. Rookie Jonathan Williams could make a push for the #2 job later this year.

The Bills have released RB Karlos Williams. NFL Network's Ian Rapoport hears that the move was performance-based, rather than off-field. Williams reported to the team overweight this offseason and was behind LeSean McCoy, Mike Gillislee, Jonathan Williams and possibly Reggie Bush on the depth chart. It still seems like a short-sighted move by Buffalo, though. Williams wasn't costing much and flashed big-time ability as a rookie. It shouldn't take him long to find a new home. We'd hang on to Williams in dynasty leagues.

The Bills and RB Reggie Bush are finalizing a 1-year contract, according to insider Jason La Canfora. Bush's 2015 season with the 49ers ended on November 1 with a torn MCL. He's 31 now and has averaged just 3.9 yards per carry and 6.2 yards per catch over the past 2 years. Bush is no more than a change-of-pace option at this point -- and it's unclear whether he'll be effective even in that role. He's no threat to RB LeSean McCoy's workload and will need to beat out Mike Gillislee and Jonathan Williams for the #2 RB job while Karlos Williams serves his 4-game suspension.

ESPN's Adam Schefter reports that 49ers RB Reggie Bush will miss the rest of the season with a torn MCL suffered in Sunday's loss to the Rams.  It's at least better for his 2016 outlook than the previously reported torn ACL.  Still, Bush turns 31 in March and had already lost a few steps.  He doesn't figure to draw much interest in free agency this offseason.

49ers RB Reggie Bush is believed to have a torn ACL, according to NFL Network's Ian Rapoport.  He'll undergo an MRI to confirm.  It'd obviously end Bush's season and also put his career on the ropes.  Bush had already lost a few steps and turns 31 in March.

49ers RB Reggie Bush injured his left leg on a punt return in the 1st quarter of Sunday's game.  He had to be carted off and won't return.  Already without RB Carlos Hyde, the Niners are now left with only RBs Mike Davis and Kendall Gaskins.

Update: Bush is questionable to return with a knee injury.

The 49ers have ruled RB Carlos Hyde out for Sunday's game at St. Louis because of the stress fracture in his foot, according to Matt Maiocco of CSN Bay Area. HC Jim Tomsula had announced Hyde as a game-time decision earlier Friday, but he and the other coaches reportedly met after practice and decided to have Hyde skip the trip. That leaves the Niners backfield to Reggie Bush, Mike Davis and Jarryd Hayne -- and even more worthy of avoiding in your fantasy football league.

49ers RB Carlos Hyde will be a game-time decision for Sunday's tilt with the Rams.  He's officially listed as questionable after not practicing all week.  Insider Matt Maiocco reports that Hyde is dealing with a stress fracture in his mid-foot area that will likely require surgery this offseason.  The 2-5 Niners would be wise to play it safe with 1 of their best offensive players.  Even if Hyde is active, he's not a recommended fantasy play vs. a stout Rams run defense.  If Hyde sits, RBs Mike Davis and Reggie Bush figure to share backfield duties.

49ers RB Reggie Bush (calf) did not practice all week and is doubtful for Sunday’s game against the Ravens. His absence will mean a 3-down role for RB Carlos Hyde.

49ers RB Reggie Bush re-injured his calf in Sunday night's loss to the Giants.  HC Jim Tomsula said Monday that Bush's Week 6 status is uncertain.  He missed 2 weeks with the previous calf injury.

49ers RB Reggie Bush (calf) is active for today’s game against the Packers. He practiced all week and shouldn’t have any limitations. Bush figures to steal passing-down work from RB Carlos Hyde. There could be a bunch of that as San Francisco tries to keep up with Aaron Rodgers and Co.

49ers RB Reggie Bush (calf) put in a full week of practice and is probable for Sunday's game against the Packers.  He's set to return after lasting just 8 snaps in San Francisco's opener.  Bush figures to steal passing-down work from RB Carlos Hyde. There could be a bunch of that as San Francisco tries to keep up with Aaron Rodgers and Co. this weekend.

49ers RB Reggie Bush (calf) returned to a limited practice on Wednesday.  It gives him a shot to play against the Packers this weekend.  When healthy, Bush will play a passing-down role that could have him busy on a San Francisco team that will be playing from behind often.

49ers RB Reggie Bush (ankle) has been downgraded to out for Sunday's game against the Cardinals.  He was originally listed as doubtful but never had a chance to play after missing practice all week.  Consider Bush questionable for Week 4.  Carlos Hyde will serve as a 3-down back vs. Arizona.