The Rams will test RB Darrell Henderson's injured thigh before today's game vs. the Jaguars, but the team is "not optimistic" about his chances of playing, ESPN's Adam Schefter reports. Henderson got in just a limited practice on Friday, and the Rams shouldn't feel any need to push him in an easily winnable game. We won't get Los Angeles' inactives until a little after 2:30 pm ET, but fantasy owners should assume at this point that Henderson won't play. That'd leave Sony Michel as the Rams' lead back and a RB1 in fantasy lineups. Mekhi Sargent is the only other RB on the roster.

Update: NFL Network's Ian Rapoport tweets that Henderson is "hopeful" to play today but "may not have a full workload." We'll look for further updates.

The Titans waived RB Mekhi Sargent from the practice squad and replaced him with RB D'Onta Foreman. Foreman was a 3rd-rounder back in 2017 but has totaled just 29 carries since tearing his Achilles in November of his rookie year. He's unlikely to emerge as a fantasy factor but is at least worth monitoring in Tennessee's Henry-less backfield.

Titans RB Derrick Henry suffered a "potentially" season-ending foot injury in yesterday's win over the Colts, ESPN's Adam Schefter reports. "Henry is undergoing an MRI today to determine the full extent of the damage," Schefter adds. We'll update Henry's status as soon as we know more, but this injury obviously has major fantasy implications. Tennessee only has RBs Jeremy McNichols and Dontrell Hilliard behind Henry on the depth chart right now. RB Mekhi Sargent is on the practice squad. None of those guys are fit to handle anywhere close to Henry's volume. The Titans could add a RB before Tuesday's trade deadline. But we'll likely see them shift significantly toward the pass for as long as Henry is sidelined. It's good news for QB Ryan Tannehill and WR A.J. Brown.

Titans RB Darrynton Evans (knee) has been placed on IR. He'll miss at least the first 3 games of the season. With Evans out and RB Jeremy McNichols on the COVID list, Mekhi Sargent is currently Tennessee's #2 RB.