49ers RB Trey Sermon is active for today’s game against the Eagles. The rookie, of course, was a healthy scratch behind Raheem Mostert, Elijah Mitchell and JaMycal Hasty for the opener. Mostert is done for the season, but Mitchell, Hasty and Trenton Cannon are active today. Your guess as to how much work Sermon will receive is as good as our’s. Mitchell is expected to "carry the load," according to NFL Network's Ian Rapoport.

NFL Network's Ian Rapoport hears that 49ers RB Elijah Mitchell is expected to "carry the load" in today's game against the Eagles. Rapoport adds that both RBs Trey Sermon and JaMycal Hasty will play, but it sounds like Mitchell is in for another hefty workload. He's an upside fantasy play today.

49ers HC Kyle Shanahan said Monday that RB Trey Sermon will be active for Week 2. Sermon was a surprise healthy scratch for the opener after looking like a top 2 RB on the depth chart throughout the offseason. But with RB Raheem Mostert out for the season, San Francisco is down to Sermon, Elijah Mitchell and JaMycal Hasty on the active roster. (Plus Kerryon Johnson on the practice squad.) Of course, it remains to be seen how touches will be divvied among those guys. Sermon would be a risky Week 2 fantasy play -- but he should certainly remain on rosters.

49ers RB Raheem Mostert announced on social media that he'll undergo season-ending knee surgery after consulting with multiple doctors. So, if you weren't already planning to, you can safely drop Mostert from all redraft rosters. San Francisco is left with Elijah Mitchell, JaMycal Hasty and Trey Sermon at RB. All 3 figure to be active for Week 2. It's also worth noting that RB Jeff Wilson (knee) is eligible to come off the PUP list in Week 7. You can see where all of those guys sit in our updated Rest-of-Season Rankings.

Niners RB Raheem Mostert has chipped cartilage in the knee he injured Sunday. ESPN’s Nick Wagoner reports that he’ll land on IR and is expected to miss 8 weeks. Elijah Mitchell took control of the backfield after Mostert left in Detroit, with JaMycal Hasty involved as well. We’d bet on Trey Sermon being active at Philly in Week 2. We’ll see about the workload split. Obviously, we have to assume that Mitchell will lead the way again — barring reports to the contrary.

49ers RB Trey Sermon is inactive for today's game against the Lions. It's a major surprise -- and leaves Raheem Mostert as San Francisco's clear lead RB in a dream matchup. Mostert is a borderline must-start in fantasy. RBs JaMycal Hasty and Elijah Mitchell are behind Mostert today.

The 49ers released RB Wayne Gallman. A noteworthy signing back in April, the 49ers proceeded to retain Raheem Mostert and draft Trey Sermon and Elijah Mitchell. That trio will enter the regular season filling San Francisco's depth chart, along with JaMycal Hasty. (Jeff Wilson remains on the PUP list.)

49ers RB Raheem Mostert got the start in Sunday's preseason finale and played all 10 snaps on the 1st possession. RB Trey Sermon then played all 14 snaps on the 2nd possession. Those 2 will open the season sharing backfield work. The exact split between them remains uncertain.

The 49ers are holding RB Trey Sermon out of Sunday night's preseason game against the Chargers. The rookie reportedly sustained a mild ankle injury during the practice week. According to Niners Nation, he returned to the field for the practice in which he came up "gimpy." That indicates it's not an issue we need to worry about. Raheem Mostert and Elijah Mitchell also won't play in the game, leaving more reps for Wayne Gallman and JaMycal Hasty.

The Athletic's believes 49ers RB Trey Sermon might play a role similar to the one Tevin Coleman played back in 2019. "The 49ers liked to begin games with Tevin Coleman at tailback, which both tenderized the defense and kept the 49ers’ home-run hitter, Raheem Mostert, fresh." That season, Coleman out-carried Mostert 137 to 112 in their 14 games together. Such a split would be a win for Sermon in his rookie season. The takeaway here, though, is that it'll be a committee attack in San Francisco's backfield this year.

49ers RB Trey Sermon has "made a strong first impression, particularly as a pass-catcher out of the backfield," according to ESPN's Nick Wagoner. Sermon soaked up 1st-team reps in minicamp with RBs Jeff Wilson and Raheem Mostert sidelined with knee issues. The pass-catching comment is particularly noteworthy since Sermon arrives to the NFL with a modest 48 receptions across 4 college seasons. We'll be keeping a close eye on this 49ers backfield in training camp and preseason. Sermon has been leaving the board in the 6th round of recent FFPC best-ball drafts.

49ers RB Jeff Wilson will start the season on the PUP list after his surgery to repair a torn meniscus, GM John Lynch said. That means Wilson will miss at least the first 6 games of the season. And he might find playing time tough to come by after that with Trey Sermon, Raheem Mostert, Wayne Gallman and Elijah Mitchell all vying for snaps. Wilson is undraftable right now.

49ers RB Jeff Wilson recently underwent surgery to repair a torn meniscus in his knee, NFL Network's Mike Garafolo reports. Wilson is expected to be sidelined 4 to 6 months, which keeps him out until sometime between mid-September and mid-November. He signed a fully guaranteed 1-year, $2 million deal this offseason, so Wilson's roster spot should be safe. But he's a candidate to open the season on the PUP list. We'll keep an eye on his rehab this summer, but Wilson isn't worth a pick in early fantasy drafts. His injury makes the 49ers backfield a bit less crowded, with Raheem Mostert, Wayne Gallman and rookies Trey Sermon and Elijah Mitchell now vying for snaps. The hype train is speeding down the tracks for Sermon, who's going in the 7th round of recent FFPC drafts.

The 49ers have added Louisiana RB Elijah Mitchell to their backfield crowd in the 6th round of the 2021 NFL Draft. Mitchell sports impressive testing numbers, including a 4.35-second pro day 40, an 83rd-percentile vertical, a 94th-percentile broad jump and a 71st-percentile 3-cone drill. His production for the Ragin’ Cajuns was fine, but a strong O-line certainly helped his 6.2-yard rushing average. Mitchell also spent his whole college career splitting touches basically evenly with limited prospect Trey Ragas. Sophomore Chris Smith tied Mitchell for the backfield lead with 16 receptions in 2020. He'll face even stiffer competition in San Francisco, which returns Raheem Mostert, Jeff Wilson and JaMycal Hasty, added Wayne Gallman and already drafted Trey Sermon. We didn't like Mitchell as more than a late consideration in rookie drafts heading in. He doesn't look any more attractive now. Mitchell will need to fight for a spot on the 2021 roster.

The 49ers traded up to select Ohio State RB Trey Sermon with the 88th overall pick of the 2021 NFL Draft. Sermon opened his college career solidly at Oklahoma, averaging 5.9 yards per rush and scoring 20 total TDs over his 1st 2 seasons. But he fell out of favor with the coaching staff there before transferring to Ohio State for his final season. Sermon spent most of 2020 splitting touches with Master Teague but closed out the year with a 29-331-2 rushing line in the Big Ten championship game win over Northwestern and then a 31-193-1 outing in the semifinal win over Clemson. Sermon brings enough size (6’0, 215), tested well athletically and put a nice blend of running skills on his college tape. There’s 3-down upside to his game, though he’s more likely headed for some level of backfield share in San Francisco alongside Raheem Mostert and Jeff Wilson. It’s a strong running game under HC Kyle Shanahan, though, so this is a nice landing spot.