Colts RB Zack Moss led the backfield touches by a wide margin with 18 attempts for 70 rushing yards in Week 4 vs. the Rams. Teammate Trey Sermon played some, logging 3 carries for 7 yards, but was otherwise an afterthought. Moss has been a fun story for fantasy, but Week 5 marks the point in time when Jonathan Taylor is eligible to return from IR. There haven’t seemed to be any positive developments regarding Taylor’s request for a long-term deal or any progress on a trade, so it’s safe to assume that he’ll be the lead back next week vs. the Titans. It’ll be worth keeping track of news this week in case anything happens, however.

Colts RB Zack Moss once again dominated the workload on Sunday, carrying the ball 30 times for 112 rushing yards to go along with a 17-yard receiving TD in Week 3 vs. the Ravens. Teammate Trey Sermon provided some relief with 5 carries for 17 yards and 1 catch for 4 receiving yards. This is the Zack Moss Show until Jonathan Taylor gets activated off of IR. Fantasy managers who took a shot on the veteran back are being rewarded handsomely. Moss will be an exciting start again next week against the Rams.

The Colts have released RB Deon Jackson, per NFL Network's Ian Rapoport. RB Trey Sermon was elevated from the practice squad in a corresponding move, so he'll fill a back up role behind Zack Moss.

The Eagles released RB Trey Sermon. Philly will carry RBs D'Andre Swift, Kenneth Gainwell, Rashaad Penny, and Boston Scott into Week 1. We're expecting that to be the order in terms of snaps to start. But this figures to be an ever-evolving backfield throughout the season.

"Signs are pointing to a running back by committee in Philadelphia," ESPN's Tim McManus writes. Five Eagles RBs -- D'Andre Swift, Rashaad Penny, Kenneth Gainwell, Boston Scott, and Trey Sermon -- have received first-team reps in camp. McManus expects Swift, Penny, and Gainwell to all be in the mix for regular-season touches, "with matchups and in-game performance likely to sway how much each player is utilized in a given week." That sounds like a fantasy nightmare. On the plus side, we know this will be a productive offense and running game. And an injury to any one of those top three would make the other two much better fantasy plays. This is still a backfield to invest in at the right price. Penny remains our favorite value on the bunch, with an ADP in late Round 9.

Eagles RB Miles Sanders racked up 134 yards and 2 TDs on 27 carries in Sunday's win over the Jaguars. He handled 79.4% of Philadelphia's RB rushes and 3 of the 5 backfield targets. Sanders caught 2 of those for another 22 yards. Kenneth Gainwell claimed the other 2 targets, turning them into just 1 catch for a loss of 2 yards. Gainwell added a 10-yard TD run but totaled only 19 yards on 5 attempts. With Boston Scott out, Trey Sermon claimed the other 2 carries and took them for gains of 14 and 5 yards. It was the largest carry total of Sanders' career and just his 4th game ever with 20+ rushes. He rushed 13, 17 and 15 times over this season's 1st 3 contests.

Eagles RB Boston Scott (ribs) is out for Sunday's game vs. the Jaguars. He's totaled 10 carries and 1 target through 3 games, so his absence could mean a few extra touches for RBs Miles Sanders and/or Kenneth Gainwell. Trey Sermon figures to be active as Philly's #3 RB on Sunday.

The Eagles on Thursday claimed RB Trey Sermon off waivers. ESPN's Adam Schefter reports that the team had previously discussed a trade with the 49ers. Sermon took less than 2 full years to bust his way off the roster of the team that drafted him in Round 3. So it's tough to bet on a big impact from him. But he's immediately the heaviest RB in the Philly backfield. We'll see whether than can make Sermon a quick factor in short-yardage situations.

ESPN's Field Yates reports that the 49ers have waived RB Trey Sermon. That leaves 4 RBs on the roster: Elijah Mitchell, Tyrion Davis Price, Jeff Wilson Jr. and Jordan Mason. We'll see exactly how things sort out behind (or alongside?) Mitchell. Kyle Shanahan backfields have been productive enough that all 4 players are worth a look in fantasy football leagues of varying sizes.

The 49ers kept 5 RBs on their initial 53-man roster: Elijah Mitchell, Jeff Wilson, Trey Sermon, Ty Davis-Price and Jordan Mason. Mitchell is the clear lead back heading into Week 1, but keeping 5 RB is another sign that San Francisco is worried about Mitchell holding up. Unfortunately, there's no clear-cut handcuff to Mitchell at this point.

There's been some positive buzz on 49ers RB Trey Sermon this month, but insider Matt Maiocco believes he's on the roster bubble. "If Sermon were not a third-round pick a year ago, there probably would not be much of a conversation about his status," Maiocco writes. He has RBs Elijah Mitchell, Ty Davis-Price and Jeff Wilson as locks to make the team, with Sermon, JaMycal Hasty and Jordan Mason fighting for the final spot. There's no clear-cut handcuff to Mitchell, but Davis-Price and Wilson are better last-round fliers than Sermon.