Rams WR Van Jefferson (knee) is out for Thursday night's opener vs. the Bills. He didn't practice all week, so a Week 2 return doesn't look particularly likely. Jefferson's snaps are expected to be picked up by a committee of WRs Tutu Atwell, Ben Skowronek and Brandon Powell. None is a viable fantasy play outside of DFS showdown contests. WR Cooper Kupp, WR Allen Robinson and TE Tyler Higbee should be the clear focal points of the Rams' passing game against Buffalo.

The Athletic's Jourdan Rodrigue wrote recently that Rams WR Van Jefferson would take over as the team's WR1 should teammate Cooper Kupp (hamstring) not play in Week 1. HC Sean McVay shared on Thursday that Kupp's game status is uncertain after the veteran suffered a setback in his injury recovery the same day. The season-long fantasy impact of this news may not be much, but take note of Jefferson as someone to look at for relief in deeper leagues or certain DFS formats. See where these Rams wideouts appear in our current WR rankings.

Rams WR Van Jefferson (knee) is active for today’s game vs. the Bucs. He was limited in practice all week, so it’s safe to assume that Jefferson still isn’t at 100% after that early-August knee surgery. He shouldn’t be in season-long fantasy lineups.

Rams WR Van Jefferson (knee) was limited in practice all week and is listed as questionable for Sunday’s game vs. the Bucs. HC Sean McVay said Friday that Jefferson will play, but it sure looks like he’s not at 100% yet.

Rams HC Sean McVay said Friday that WR Van Jefferson (knee) will play vs. the 49ers this weekend and have his "normal workload," per ESPN's Sarah Barshop. McVay added that Jefferson will be monitored throughout the game. A "normal workload" for Jefferson last year meant an 80% snap rate and 14.7% target share. It'd be a little surprising if Jefferson did that much in his 1st game since early-August knee surgery, but it sounds like McVay expects him to contribute. We'd try not to use Jefferson in season-long fantasy lineups this week, but he's an intriguing DFS flier.

Rams WR Van Jefferson (knee) put in a limited practice on Wednesday. He was just designated to return from IR earlier this week after early-August knee surgery. We'll see if Jefferson is ready for this weekend's game vs. the 49ers.