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49ers RB Elijah Mitchell is expected to miss "a few weeks (or more)" with the knee injury he suffered in Sunday's opener vs. the Bears, per NFL Network's Ian Rapoport. Mitchell is undergoing an MRI on Monday to get a full view of the damage to the knee. We should get a more concrete timeline for his return over the next couple days, but fantasy owners need to start making replacement plans. Jeff Wilson is the favorite to take over as San Francisco's lead RB, but Jordan Mason and Ty Davis-Price are also worth stashing.

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Niners HC Kyle Shanahan confirmed Monday that RB Elijah Mitchell did suffer an MCL sprain Sunday against the Saints. He's expected to miss 6-8 weeks. When Mitchell suffered the same injury to his other knee back in Week 1, he remained out until Week 10. Expect this injury to knock Mitchell out for at least the rest of the regular season. We'll see about the playoffs (for him and the 49ers).

49ers RB Elijah Mitchell suffered a "possible" MCL sprain in Sunday's win over the Saints, HC Kyle Shanahan said afterward. Mitchell missed 8 weeks with a sprained MCL earlier this season, although Shanahan said this one isn't believed to be as serious. We should learn more about Mitchell's status on Monday.

49ers RB Elijah Mitchell is questionable to return to Sunday's game vs. the Saints with a knee injury. We'll pass along an update when we get one.

Update: Mitchell has been ruled out.

RB Elijah Mitchell led the 49ers in carries Sunday night in his 1st action since a Week 1 knee injury. He carried 18 times for 89 yards, beating Christian McCaffrey by 4 attempts and 51 yards. McCaffrey claimed the lone TD between them and caught 4 of 6 targets to add 39 yards. Mitchell drew 2 targets and caught 1 for a loss of a yard. We'll see about this backfield plan going forward. But the even split in Mitchell's return sets McCaffrey up as a "sell-high" candidate in redraft leagues.

49ers RB Elijah Mitchell (knee) will be activated from IR and play vs. the Chargers on Sunday night, HC Kyle Shanahan said. Mitchell has been out since going down with a sprained MCL in the season opener. He figures to return as the #2 RB behind Christian McCaffrey. Mitchell is unlikely to hold standalone fantasy value but is worth rostering as the CMC handcuff.

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