A source tells ESPN's Josh Weinfuss that there's "little doubt" QB Kyler Murray has a torn right ACL. “Doesn’t look good," HC Kliff Kingsbury said after the loss. Murray is scheduled for an MRI on Monday, so we should get confirmation on his status later today. A torn ACL would end his 2022 season and threaten his availability for the start of the 2023 campaign.

Cardinals QB Kyler Murray went down with a non-contact injury on the 3rd play from scrimmage in Monday night's game vs. the Patriots. Murray had to be carted off the field and is certainly done for the night. We'll update Murray's status when we know more. QB Colt McCoy has replaced Murray.

Update: Murray has a knee injury and is officially "questionable" to return, the team announced.

Update: Murray has been downgraded to out.

Cardinals WR Rondale Moore (groin) is out for Monday night's game vs. the Patriots. WR Greg Dortch (thumb) isn't listed on the final injury report after a full week of practice, putting him in line to operate as Arizona's primary slot receiver this week. Dortch has averaged 8.3 targets in 4 games with a 70+% snap rate this season -- although we wouldn't bet on quite that much volume this week with WRs DeAndre Hopkins and Marquise Brown both playing.

Cardinals WR Rondale Moore (groin) did not practice on Thursday. WR Greg Dortch (hand) was a full participant, so he should be ready for Monday night's game vs. the Patriots. If Moore misses that one, Dortch will be in the PPR WR3 discussion.

Cardinals HC Kliff Kingsbury expressed "optimism" about WR Greg Dortch's chances of returning from his thumb injury for Monday night's game vs. the Patriots, according to insider Darren Urban. Kingsbury reportedly didn't sound optimistic about WR Rondale Moore's status for that one. If Moore is out and Dortch in, Dortch will be a viable WR3 or flex play in PPR leagues.

Cardinals QB Kyler Murray threw for 191 yards and 2 TDs (plus an INT) in Sunday's return from 2 games lost to a hamstring injury. He added 56 yards and a TD on 7 carries. Murray now gets a Week 13 bye and then a fairly neutral closing schedule -- with the highlight a Week 17 trip to Atlanta.

WR Marquise Brown led the Cardinals with 8 targets in Sunday's return from IR. He also played 15 more snaps than WR DeAndre Hopkins and ran 3 more routes. Hopkins still drew 6 targets and caught 4 balls for 87 yards and a TD. Brown managed 6 receptions for 46 yards. RB James Conner was the only other Cardinal to catch more than 1 pass. Brown's return could limit the target upside for Hopkins going forward, but there should be room for both at least as long as slot WR Rondale Moore is out.

Cardinals RB James Conner rushed 25 times for 120 yards (4.8 per carry) in Sunday's narrow loss to the Chargers. He added 3 catches for 20 yards and a TD among 3 targets. Keaontay Ingram claimed the only 2 other RB carries, while Corey Clement drew the only other RB target. Conner now gets a Week 13 bye and then a tough trio of RB-scoring matchups.

Cardinals WR Greg Dortch (thumb) is inactive for today’s game vs. the Chargers. With WR Rondale Moore (groin) also out, Arizona is down to WRs DeAndre Hopkins, Marquise Brown, A.J. Green, Robbie Anderson and Andre Baccellia.

Cardinals WR Marquise Brown (foot) is officially active for today’s game vs. the Chargers. It’ll be his 1st action since Week 6. It’s unclear exactly how big a role Brown will play, but Arizona could certainly use him with both WR Rondale Moore (groin) and WR Greg Dortch (thumb) inactive. Consider Brown a risk/reward WR3 play today.

Cardinals WR Greg Dortch (thumb) is not expected to play Sunday against the Chargers, according to ESPN's Adam Schefter. That will leave Arizona without its top 2 slot WRs. That leaves target opportunity for TE Trey McBride.

The Cardinals have activated WR Marquise Brown from IR. Brown has been out since breaking a bone in his left foot in Week 6 but should find targets available. Arizona will be without slot man Rondale Moore, and slot backup Greg Dortch is questionable.

Cardinals QB Kyler Murray (hamstring) put in a full week of practice and isn’t listed on the final Week 12 injury report. "He feels great, he feels 100%,” HC Kliff Kingsbury said Friday. “If there was anything less than that we would have maybe waited, but he feels full go, so we're going to get him going." Murray will be back under center for Sunday’s game vs. the Chargers.

Cardinals WR Rondale Moore (groin) is out for Sunday's game vs. the Chargers. WR Greg Dortch (thumb) is listed as questionable. He didn't practice all week but will be a game-time decision, according to HC Kliff Kingsbury. Dortch will have some WR3 appeal in PPR leagues as Arizona's slot receiver if he suits up.

Cardinals WR Marquise Brown (foot) is expected to be activated from IR and play vs. the Chargers on Sunday, HC Kliff Kingsbury said. Brown has been practicing for a couple of weeks now after going down back in Week 6. He carries elevated risk in his 1st game back but certainly has enough upside to make sense in plenty of fantasy lineups. Brown averaged 10.7 targets, 7.2 catches, 81 yards and .5 TDs over the first 6 games of the season -- although none of those came with WR DeAndre Hopkins.

Cardinals WRs Rondale Moore (groin) and Greg Dortch (thumb) remained sidelined on Thursday. Both guys are looking unlikely to play vs. the Chargers this weekend, but check back tomorrow for another update.

Cardinals QB Kyler Murray (hamstring) was a full participant in Wednesday's practice. It's his 1st full practice since going down in Week 9, putting Murray on track to return for this weekend's game vs. the Chargers.

Cardinals WRs Rondale Moore (groin) and Greg Dortch (thumb) did not practice on Wednesday. Both of Arizona's slot receivers are in danger of missing this weekend's game vs. the Chargers. We'll see if they're able to practice tomorrow.

Cardinals HC Kliff Kingsbury said Wednesday that QB Kyler Murray (hamstring) is "trending in the right direction" to return for Sunday's game vs. the Chargers. Murray said that he "feels good" and expects to start that game. Arizona has seemingly played it very safe with this hamstring, so we're expecting Murray to be very close to 100% if he suits up this weekend.

Cardinals HC Kliff Kingsbury said Tuesday that QB Kyler Murray has progressed "quite a bit" with his hamstring injury. Kingsbury did not say whether Murray will be back for Week 12, though, saying that he needs to be "full throttle" before getting back under center. We'll track Murray's status throughout the week. Kingsbury also said that QB Colt McCoy is "banged up" with elbow, hand and knee injuries.