Giants RB Saquon Barkley is believed to have a low-ankle sprain and will "likely" miss next weekend's game vs. the Rams, according to NFL Network's Ian Rapoport. "He’ll have more tests, but he’s best characterized as week-to-week," Rapoport adds. "A fast healer, Barkley will work to miss only one week." We'll look for a more concrete timetable for Barkley's return. Devontae Booker operated as New York's clear lead back after Barkley exited today's game, handling 19 of the 20 RB opportunities.

Giants RB Saquon Barkley (ankle) is officially inactive for tonight's game vs. the Seahawks. He put in three limited practices this week and has a shot to return for Week 5. Matt Breida figures to serve as New York's lead back tonight after playing 82% of the offensive snaps last week. RBs Gary Brightwell and Eric Gray are also active.

NFL Network's Ian Rapoport confirms that Giants RB Saquon Barkley (ankle) is not expected to play vs. the Seahawks tonight. But Barkley is "steadily getting better" and has a "realistic chance" to return for Week 5, Rapoport adds. We'll keep tabs on Barkley's progress throughout this week, leading up to Sunday's game vs. the Dolphins.

Giants RB Saquon Barkley (ankle) is doubtful for Monday night's game against the Seahawks. That means Matt Breida should again run as New York's top back. He'll get a more favorable matchup than Week 3, when a TD made his fantasy line against the 49ers. Breida still carries limited upside but is an option for needy Week 4 fantasy lineups. Check your Team Intel page to see how Breida compares with your other options.

Giants RB Saquon Barkley (ankle) remained limited in Friday's practice. HC Brian Daboll said Barkley "did good" on Thursday, per ESPN's Jordan Raanan, so it sounds like that injured ankle has responded well so far. We'll see what Barkley does on Saturday and how he's listed on the final injury report for Monday night's game vs. the Seahawks.

Giants RB Saquon Barkley (ankle) was listed as a limited participant in Thursday's practice. NFL Network's Ian Rapoport described Barkley's status for Monday night's game vs. the Seahawks as a "wait-and-see" situation, adding that Barkley "has a long way to go." We're still not projecting him to play this week but will continue to monitor his progress over the next few days.