The 49ers have downgraded WR Brandon Aiyuk to out for tonight's game against the Giants because of his shoulder injury. That should make Jauan Jennings the No. 2 WR for the upside matchup. Aiyuk (14) and Deebo Samuel (16) have accounted for 88.2% of WR targets for San Francisco through two weeks, with Jennings claiming the only other four. Jennings posted three games of 4+ receptions last year, though none came with Brock Purdy behind center. Jennings makes for a nice play in Thursday night DFS showdowns. He's too much of a longshot for most season-long redraft formats, though. Seventh-round rookie Ronnie Bell has been the No. 4 WR in playing time so far and matched Jennings in snaps in Week 2. He has yet to see a target, though.

Niners WR Brandon Aiyuk tallied 5 receptions for 109 yards in Sunday's loss to the Bengals. His 9 targets ranked second on the team, while he accounted for 29.9% of the team's receiving yards. It was Aiyuk's third game of the season with 100+ yards. The 9 targets were his second-most this season. We'll see whether WR Deebo Samuel can get back onto the field after the Week 9 bye and how that affects target shares.

49ers WR Brandon Aiyuk (shoulder) is not listed on the final Week 4 injury report. He put in a full practice on Friday and seems ready to play his usual role vs. the Cardinals this weekend. With WR Deebo Samuel banged up, Aiyuk should be in for plenty of volume.

49ers WR Brandon Aiyuk (shoulder) remained limited in Thursday's practice but was out of his non-contact jersey, according to The Athletic's David Lombardi. Aiyuk is trending toward returning for this weekend's game vs. the Cardinals. We'll see how he's listed on the final injury report tomorrow.

49ers WR Brandon Aiyuk (shoulder) was limited in Wednesday's practice. He was seemingly close to playing last Thursday night, so we're tentatively expecting him back for this weekend's game vs. the Cardinals.

49ers WR Brandon Aiyuk (shoulder) is officially inactive for tonight's game vs. the Giants. He seemed relatively close to playing tonight, so we're tentatively expecting him back for Week 4. Aiyuk's absence should make San Francisco's offense even more concentrated, with RB Christian McCaffrey, WR Deebo Samuel, and TE George Kittle dominating touches.