The 49ers officially put an end to WR Brandon Aiyuk's season on Saturday, placing him on the reserve/left squad list. Aiyuk has not played since suffering a multi-ligament knee injury in Week 7 of the 2024 season. It's unclear exactly where he's at in his rehab, but Aiyuk never seemed likely to play this year after we learned the team voided the more than $25 million guaranteed for 2026 in his contract. Aiyuk is expected to be released this offseason and figures to draw plenty of interest. He turns 28 in March and has averaged 62 receiving yards per game for his career.

The 49ers have voided the more than $25 million guaranteed for 2026 in WR Brandon Aiyuk's contract, according to The Athletic. Aiyuk reportedly skipped meetings and other activities in recent months, as he's continued to work back from his October 2024 knee injury. Aiyuk will not be contesting the voided money. There have been "repeated overtures from team officials and even players to try to bring Aiyuk back into the fold," per The Athletic. But "it’s now likely that the 27-year-old has played his last game with the franchise." Aiyuk is expected to be released after the season.

49ers GM John Lynch stated that he "doesn't think" WR Brandon Aiyuk will be cleared for Week 1. Aiyuk tore his ACL and MCL last October in Week 7. Week 1 will mark a little over 10 months since sustaining the injury. There has been no official timeline laid out by the team for Aiyuk's return.

Per beat writer Matt Barrows, 49ers rookie WR Jordan Watkins is "in position to be the 49ers’ No. 3 or 4 wide receiver and perhaps serve as the team’s primary punt returner.” Teammates have reportedly praised his "maturity and mental sharpness." There’s some appeal here in the deepest of fantasy leagues, especially with San Francisco banged up at WR. Brandon Aiyuk remains without a timetable to return, while Ricky Pearsall and Jauan Jennings have dealt with summer injuries. Ultimately, Watkins is best viewed as a dynasty stash.

According to ESPN’s Nick Wagoner, the 49ers are still unsure when WR Brandon Aiyuk will return. Aiyuk suffered a multi-ligament knee injury back in Week 7 of the 2024 campaign. With WR Deebo Samuel now in Washington, there are plenty of targets available in San Francisco.

49ers WR Deebo Samuel will miss "a couple of weeks" with a calf injury suffered in Sunday's loss to the Vikings, HC Kyle Shanahan said.

49ers WR Ricky Pearsall is officially off of the Active/NFI list. He appears recovered from his hamstring injury and is participating in training camp.

49ers WR Brandon Aiyuk (shoulder) is not listed on the final Week 4 injury report. He put in a full practice on Friday and seems ready to play his usual role vs. the Cardinals this weekend. With WR Deebo Samuel banged up, Aiyuk should be in for plenty of volume.

49ers WR Brandon Aiyuk (shoulder) remained limited in Thursday's practice but was out of his non-contact jersey, according to The Athletic's David Lombardi. Aiyuk is trending toward returning for this weekend's game vs. the Cardinals. We'll see how he's listed on the final injury report tomorrow.

The 49ers have downgraded WR Brandon Aiyuk to out for tonight's game against the Giants because of his shoulder injury. That should make Jauan Jennings the No. 2 WR for the upside matchup. Aiyuk (14) and Deebo Samuel (16) have accounted for 88.2% of WR targets for San Francisco through two weeks, with Jennings claiming the only other four. Jennings posted three games of 4+ receptions last year, though none came with Brock Purdy behind center. Jennings makes for a nice play in Thursday night DFS showdowns. He's too much of a longshot for most season-long redraft formats, though. Seventh-round rookie Ronnie Bell has been the No. 4 WR in playing time so far and matched Jennings in snaps in Week 2. He has yet to see a target, though.

49ers WR Brandon Aiyuk injured his left shoulder on the opening drive of Sunday's win over the Rams. He eventually returned to the game but ended up playing just 53% of the offensive snaps. HC Kyle Shanahan on Monday wouldn't commit to Aiyuk being available for Thursday night's game vs. the Giants. We're tentatively expecting Aiyuk to be out there for that one, but we'll watch his status over the next few days.

49ers WR Deebo Samuel led the team in receiving with 6 catches on 9 targets for 133 yards and 1 TD in Saturday's Wild Card win vs. the Seahawks. The crafty wideout also handled 3 carries for 22 yards on the ground in the contest. Samuel was seldom used in Week 18 after returning from a 3-game absence due to injury, so it's good to see his body hold up to a more significant workload. It's also worth noting that teammate WR Brandon Aiyuk is the only other 49ers' pass-catcher who logged more than 2 receptions.

49ers QB Jimmy Garoppolo does not have a Lisfranc injury and won't need surgery, ESPN's Adam Schefter reports. Garoppolo could be back in 7-8 weeks, "if rehab goes smoothly," Schefter adds. Seven weeks would put Garoppolo back on the field for the Divisional Round of the playoffs. We'll keep an eye on his progress. Garoppolo is still a guy to avoid in playoff fantasy contests, but this news helps the outlooks on San Francisco's skill-position players.

ESPN's Adam Schefter reports 49ers QB Trey Lance suffered a "significant" right ankle injury in the Week 2 win over the Seahawks. Lance is expected to need surgery that will "likely" end his season. You can hang on to him on fantasy rosters until we get official confirmation that Lance's season is over, which figures to come tomorrow. San Francisco will turn back to QB Jimmy Garoppolo, which will mean a significant shift in the offense. The 49ers' pass rate will climb, and there will be more carries to go around since Garoppolo won't be taking many.