49ers WR Brandon Aiyuk saw 8 targets in a Week 3 loss to Denver. That tied Deebo Samuel for the team lead. From 3 yards out, Aiyuk caught Jimmy Garoppolo’s only TD pass on a well-designed play where Deebo walled off the nearest defender. While George Kittle’s return adds volatility, Aiyuk remains an ascending talent with a high weekly ceiling. Don’t be surprised if he’s in the WR3 mix for Sunday’s divisional tilt with the Rams.

49ers WR Brandon Aiyuk (shoulder) is officially inactive for tonight's game vs. the Giants. He seemed relatively close to playing tonight, so we're tentatively expecting him back for Week 4. Aiyuk's absence should make San Francisco's offense even more concentrated, with RB Christian McCaffrey, WR Deebo Samuel, and TE George Kittle dominating touches.

The 49ers have downgraded WR Brandon Aiyuk to out for tonight's game against the Giants because of his shoulder injury. That should make Jauan Jennings the No. 2 WR for the upside matchup. Aiyuk (14) and Deebo Samuel (16) have accounted for 88.2% of WR targets for San Francisco through two weeks, with Jennings claiming the only other four. Jennings posted three games of 4+ receptions last year, though none came with Brock Purdy behind center. Jennings makes for a nice play in Thursday night DFS showdowns. He's too much of a longshot for most season-long redraft formats, though. Seventh-round rookie Ronnie Bell has been the No. 4 WR in playing time so far and matched Jennings in snaps in Week 2. He has yet to see a target, though.

The 49ers list WR Brandon Aiyuk (shoulder) as questionable for Thursday night's game against the Giants. ESPN's Nick Wagoner reports that HC Kyle Shanahan "indicated" Aiyuk will be a game-time decision. Fortunately, it's the first game of the week. So we'll know more before you're setting your Week 3 lineups.

49ers WR Brandon Aiyuk (shoulder) will be a game-time decision for Thursday night's meeting with the Giants, HC Kyle Shanahan said Tuesday. Aiyuk was limited in Tuesday's practice. We'll continue to look for updates on his status, but it seems like he'll come with elevated risk in Week 3 fantasy lineups if he does suit up on Thursday night.

A CT scan on 49ers WR Brandon Aiyuk's clavicle came back clean, according to The Santa Rosa Press Democrat's Jack Hammer. "His ability to play Thursday night will be all about pain tolerance," Hammer adds. We'll keep an eye on Aiyuk's status and will get San Francisco's inactives around 7 pm ET on Thursday.