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49ers QB Trey Lance (knee) did not practice on Wednesday. QB Jimmy Garoppolo (calf) was limited and is expected to be a full-go later this week, HC Kyle Shanahan said. Garoppolo remains in line to start Sunday night's game vs. the Colts.

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NFL Network's Tom Pelissero confirms that 49ers QB Trey Lance will miss the rest of the 2022 season after undergoing ankle surgery on Monday morning. Lance suffered a fractured and dislocated ankle, Pelissero reports. It's similar although slightly less severe than the injury Cowboys QB Dak Prescott suffered in October 2020. Prescott was fully cleared for the start of training the following summer and played Week 1, but it's worth remember that he set a career-low in rushing yards per game in 2021. We'll monitor Lance's rehab and hope he quickly regains his mobility.

ESPN's Adam Schefter reports 49ers QB Trey Lance suffered a "significant" right ankle injury in the Week 2 win over the Seahawks. Lance is expected to need surgery that will "likely" end his season. You can hang on to him on fantasy rosters until we get official confirmation that Lance's season is over, which figures to come tomorrow. San Francisco will turn back to QB Jimmy Garoppolo, which will mean a significant shift in the offense. The 49ers' pass rate will climb, and there will be more carries to go around since Garoppolo won't be taking many.

49ers QB Trey Lance injured his right leg in the 1st quarter of Sunday's game vs. the Seahawks. He had to be carted off the field and is obviously done for the day. We'll pass along an update when we get one. QB Jimmy Garoppolo has entered for the 'Niners.

Niners QB Trey Lance completed just 13 of 28 passes for 164 yards, 0 TDs and 1 INT in Sunday's rain-soaked loss at Chicago. He added 54 yards on 13 rushes, leading the team in both categories. The day presented tough weather conditions, but we can't shrug off the performance entirely. Week 2 should bring a friendlier setup: a home date with Seattle.

Chicago has been hit with heavy rains this morning. It looks like the worst of it will be gone by kickoff of 49ers-Bears, but there will be lingering showers -- and a wet field. The forecast also calls for 15-20 mph winds. Less than ideal scoring conditions, although this looked like a low-scoring game anyways. Expect lots of running from both teams.

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