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Cardinals WR DeAndre Hopkins (hamstring) is inactive for today’s game vs. the 49ers. We’ll see if he can make it back for Week 10. With WR A.J. Green (COVID) also out, Arizona is down to WRs Christian Kirk, Rondale Moore, Antoine Wesley and Andy Isabella. Consider Kirk and Moore WR3s with Colt McCoy under center.

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ESPN's Adam Schefter reports that the NFL is suspending Cardinals WR DeAndre Hopkins 6 games for violating the PED policy. Assuming he doesn't get it reduced on appeal, Hopkins' absence creates season-opening opportunity for Arizona WRs Marquise Brown, A.J. Green and Rondale Moore -- and it delivers a big blow to any best-ball drafters who combined Hopkins with QB Kyler Murray on their early rosters. We'll watch for any further developments with the situation, but Hopkins obviously tumbles down our WR rankings.

ESPN's Adam Schefter hears that Cardinals WR DeAndre Hopkins (knee) "could be back" for the NFC Championship or Super Bowl, but that it'd be "unrealistic" to expect him back any sooner. That jibes with the 6-week timetable for return we got for Hopkins earlier this week. We'll see how Arizona deploys WRs Christian Kirk, A.J. Green, Rondale Moore and Antoine Wesley vs. the Lions today.

Cardinals WR DeAndre Hopkins is set for surgery to repair a torn MCL, according to NFL Network's Ian Rapoport. Hopkins is expected to be sidelined for 6 weeks, so he'll probably need Arizona to reach the NFC Championship to have a chance to play again this season. The last 2 games Hopkins missed, the Cardinals used A.J. Green and Antoine Wesley as their primary outside WRs, with Christian Kirk in the slot.

ESPN's Adam Schefter reports that the Cardinals expect WR DeAndre Hopkins to miss the rest of the regular season with a knee sprain. The team is "hopeful to get him back at some point in the postseason." It's worth noting here that NFL Network's Ian Rapoport reports that Hopkins is "expected to miss Sunday and likely more." Those 2 reports don't necessarily clash, but might be reason to wait before dropping Hopkins from your roster right away if you can help it. However long he's out, Hopkins' absence can only help the target outlooks for the team's other pass-catchers. Christian Kirk and A.J. Green both look like top-30 options across fantasy formats for Sunday's game at Detroit.

Cardinals WR DeAndre Hopkins "is in danger " of missing Sunday's game vs. the Lions due to a knee injury, according to NFL Network's Ian Rapoport. Hopkins is seeking more opinions on the injury, which usually isn't a good sign. We'll keep you updated on his status, but fantasy owners should be lining up backup plans for Week 15.

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