49ers HC Kyle Shanahan said after Sunday night's loss to the Bills that RB Christian McCaffrey has a PCL injury that could be season-ending. McCaffrey will likely undergo additional testing on Monday to get a better look at the damage. We should get another update on his status over the next 24 hours. McCaffrey's absence would leave Jordan Mason as San Francisco's lead back once again. He out-carried RB Isaac Guerendo 13 to four in Buffalo. Mason, who's rostered in only 37% of Sleeper leagues, is the top target on waiver wires this week.
RB Ashton Jeanty will go high in your rookie draft. But who should you target later in the first round and beyond? Check out our 2025 Dynasty Rookie Rankings to find out.
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Build an unbeatable team with these seven fantasy football sleepers. A first-time starter with QB1 upside, an under-the-radar RB with 200+ carry potential, an exciting second-year breakout WR, and more!
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Shedeur Sanders headlines the 2025 rookie QB class, but some sleepers are lying in wait. See how the QBs stack up in these 2025 Superflex Rookie Rankings.
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