Bills RB James Cook logged a season-high 22 touches in Sunday's loss to the Eagles: 16 carries and a season-high 6 receptions. It marked the third time this season he has reached 20 touches and the second such game in a row. So does that mean his role is growing? No. Cook's carry and opportunity shares have not increased the past two weeks, following the team's OC switch. In fact, Cook's 51.6% share of RB carries against Philly was his second-smallest of the season. His 53.5% opportunity share (carries + targets) was his fourth-lowest. Cook benefited in each case from high team play volume. The Bills ran a season-high 92 plays at Philadelphia and 76 in the Week 11 win over the Jets, their third-most plays of the year. Buffalo RBs, though, have also seen a boost in target share over the past two games. A 21.9% share against the Jets was the highest since the season opener -- until Sunday's 23.5% share. If that continues, Cook's fantasy numbers would certainly benefit. He has caught four passes in two straight games after reaching that number just twice through the first 10 weeks. Buffalo now heads into a Week 13 bye. Then come matchups with the Chiefs and Cowboys that should support RB targets, because each ranks among the league's toughest WR defenses. Then comes Cook's best remaining matchup (Chargers) and a Week 17 rematch with New England. The Patriots afforded him 102 total yards and a TD at 6.4 yards per touch in their first meeting. Cook should be a solid PPR contributor the rest of the way. He won't be a lock for strong touch counts, though. Latavius Murray actually played 1 more snap vs. Philly, ran six more routes, and trailed Cook by just 1 target. Ty Johnson has also worked in for 6 touches each of the past two weeks. Leonard Fournette, meanwhile, has yet to be called up from the practice squad a month after signing.

Monday night was an eventful evening for Bills RB James Cook. The second-year back tallied 12 carries for 109 rushing yards in Week 10 vs. the Broncos, the second-highest yardage total he’s recorded in 2023. He unfortunately also fumbled twice in the contest, including a lost ball on the Bills’ first play of the game. He was benched for several series thereafter before returning to the field in the second quarter. Teammate Latavius Murray saw an uptick in involvement as a result (9-68-1). It’s also worth mentioning that Leonard Fournette wasn’t brought up onto the active roster for the second week in a row. This backfield is a bit messy and will only have more complications given that the Bills’ remaining schedule ranks fourth-toughest for RBs per our adjusted fantasy points allowed. Next up on the calendar is an AFC East showdown with the Jets (19th in run defense DVOA).

Bills RB James Cook had a tough outing in Week 9 vs. the Bengals. The second-year back racked up just 39 total yards on a combined 10 touches in the contest. Fellow RB Latavius Murray was also minimally impactful, contributing a mere 10 total yards on 3 touches. It’s also notable that recent free agent signee Leonard Fournette was not promoted to the active roster on Sunday. The Bills’ run game has been largely ineffective of late, but there’s reason for fantasy managers to be optimistic moving forward. Buffalo’s remaining schedule ranks 12th-easiest for RB in adjusted fantasy points allowed.

Bleacher Report's Jordan Schultz reports that RB Leonard Fournette is planning to sign with the Bills, pending a physical. The move would add Fournette to a backfield currently led by James Cook, who ranks just 26th among RBs in PPR points per game. Adding Fournette would seem to indicate the team hopes he can at least be an upgrade over Latavius Murray and Damien Harris -- and perhaps that the Bills would like to siphon a bit more work away from Cook. The crowd will make it tough for any Buffalo RB to consistently help your fantasy lineup. We'll watch for more details on how quickly the Bills plan to bring Fournette along and how the work might be split.

Update: Fournette has passed his physical and is signing with the team's practice squad, his agents have said. Don't be surprised if the Bills elevate him as soon as this weekend.

Bills RB James Cook received 13 carries for 56 yards in Week 7 vs. the Patriots. He also hauled all 3 targets for 46 yards with a receiving TD as a pass-catcher in Sunday’s loss. Veteran back Latavius Murray produced very little as the sole RB2, posting just 28 total yards on 6 touches. With their Week 8 game vs. the Buccaneers coming on Thursday night, it’ll be interesting to see if Buffalo is inclined to more evenly distribute the workload. Regardless, Cook will be a quality RB2 option for lineups.

The Bills placed RB Damien Harris (neck, concussion) on IR. He'll miss at least the next four games and can be dropped in most fantasy leagues. RB Latavius Murray should get an uptick in work with Harris sidelined. Harris' absence can't hurt RB James Cook's volume either.

Bills RB Damien Harris (neck, concussion) is out for Sunday's game vs. the Patriots. He's averaged 4.4 carries in five healthy games this season. Expect most of that work to go to RB Latavius Murray this weekend, putting him on the RB3 radar.

Bills RB Damien Harris has a neck sprain "but is otherwise good," a source tells insider Jordan Schultz. It's excellent news after Harris was taken off the field in an ambulance during Sunday night's game vs. the Giants. We'll look for further updates on when Harris might be able to get back on the field. His absence figures to boost RB Latavius Murray's workload.

Bills RB James Cook received 14 carries for 71 yards in Week 6's win vs. the Giants. Surprisingly, the second-year back didn't register a single target or catch in the contest, the first time that's happened in the 2023 season. After Damien Harris left late in the second quarter due to a frightening neck injury, RB Latavius Murray stepped up in spelling Cook and ended Sunday night with 45 rushing yards on 12 carries. It's also worth noting that Murray received 4 red zone carries to Cook's 1 against the Giants. Though the veteran didn't find the end zone, Murray brings some fantasy viability as a decent flex option with TD upside for managers with players on bye weeks. Next week, the Bills will take on the Patriots.

Bills RB James Cook led the backfield with 15 carries and 98 yards in Week 3. He garnered only 3 targets on a day that saw Stefon Diggs dominate (37.5% target share). Cook also watched as Josh Allen and Latavius Murray tallied short-range rushing scores. It’s clear by now that the second-year back won’t carry a high TD ceiling. But his efficiency and overall touch volume suggest he can remain a strong RB2+. He draws the Dolphins at home in Week 4.

Bills RB James Cook looked explosive in Sunday’s win over Las Vegas, totaling 159 yards on 21 touches. Both figures marked career highs. The second-year back also led all early-game RBs in rush yards over expectation (+44), per ESPN’s Seth Walder. He continued to lose out on red zone work to both Damien Harris and Latavius Murray. Still, his receiving work (10 targets in two games) really helps Cook’s floor. He’ll remain an RB2 moving forward.

Bills RB Damien Harris returned to practice Wednesday after missing a little more than a week with a knee issue. He still has nearly a month to get ready for the regular-season opener but will need to battle Latavius Murray for the No. 2 job behind expected starter James Cook. Harris has moved down our 2023 fantasy football rankings since the beginning of training camp.

Joe Buscaglia of The Athletic says that Bills RB James Cook has "separated himself" from Damien Harris and Latavius Murray in training camp, furthering the notion that Cook is headed for the clear lead role. Buscaglia adds that Murray is pushing Harris for the No. 2 job with a good camp, while Harris has also dealt with injury. Buscaglia also throws in that RB Nyheim Hines was a "borderline favorite" to be the Bills' No. 2 before suffering his ACL tear. That's especially interesting because Hines garnered only six total carries and nine targets across nine games with the Bills last year after arriving from the Colts via trade. The Hines bit plus the Murray praise could signal an iffy outlook for Harris, who signed for less than $2 million on a one-year deal in free agency. Harris has already moved down our RB rankings since the start of training camp.

Bills RB Damien Harris left practice Monday with knee soreness and has yet to return, according to Matt Parrino of NewYorkUpstate.com. Latavius Murray has been filling in. We'll see how long the absence lasts and whether we get an official diagnosis. This doesn't sound like a serious issue, though, and hasn't affected Harris to date in our fantasy football RB rankings.

The Bills announced Monday morning that they have signed RB Latavius Murray to a one-year deal. It's noteworthy that he comes off the market ahead of bigger-named free agents Ezekiel Elliot, Leonard Fournette, and Kareem Hunt. But that might just indicate what Buffalo is looking for vs. what those players would seek. Murray likely won't challenge the role of Damien Harris, who signed back in March. And he shouldn't challenge James Cook's role either. Murray looks like veteran depth. We'll see whether the contract terms even make him a lock for the regular-season roster. Don't bother with Murray in your best ball drafts at this point. See where the other Bills RBs sit in our 2023 fantasy football rankings.

Broncos RB Marlon Mack will miss Sunday's finale vs. the Chargers with the hamstring injury he suffered in Week 17, according to insider Mike Klis. That'll leave Denver's backfield to Latavius Murray and Chase Edmonds. Murray tallied 12 carries and 6 targets to Edmonds' 7 carries and 3 targets in last week's loss to the Chiefs.

Broncos RB Marlon Mack hurt his hamstring in the 1st quarter of Sunday's game vs. the Chiefs and is questionable to return. His absence leaves Denver's backfield to Latavius Murray and Chase Edmonds.

Broncos RB Latavius Murray (NIR/rest) received the day off from practice on Wednesday. It's not unusual for veterans to sit out Wednesday practices, so no need for alarm. We'll check back on Murray's status for Week 17 vs. the Chiefs tomorrow.