Bills RB Nyheim Hines is expected to miss the entire 2023 season after suffering a "significant knee injury off-site," according to NFL Network's Tom Pelissero. We'll look for more details on the injury and Hines' rehab timeline. The Bills acquired him via trade last November but used him primarily in a special teams role. Hines handled just six carries and nine targets in nine regular season games -- and then zero carries and three targets in two postseason appearances. There's very little fantasy impact here, besides making RB James Cook a slightly safer bet to handle passing-down snaps.

Update: Pelissero reports that Hines was struck by a jetski. He suffered a torn left ACL, per team reporter Alaina Getzenberg.

The Bills announced Monday morning that they have signed RB Latavius Murray to a one-year deal. It's noteworthy that he comes off the market ahead of bigger-named free agents Ezekiel Elliot, Leonard Fournette, and Kareem Hunt. But that might just indicate what Buffalo is looking for vs. what those players would seek. Murray likely won't challenge the role of Damien Harris, who signed back in March. And he shouldn't challenge James Cook's role either. Murray looks like veteran depth. We'll see whether the contract terms even make him a lock for the regular-season roster. Don't bother with Murray in your best ball drafts at this point. See where the other Bills RBs sit in our 2023 fantasy football rankings.

Bills RBs totaled just 13 rushing attempts in Sunday's win over the Jets. Devin Singletary led with 8 carries for 39 yards. Rookie James Cook added 4 carries for just 6 yards. Nyheim Hines claimed the other, gaining 3 yards. The trio also combined for just 4 targets. Singletary led there as well, catching 1 of his 2 looks for 4 yards. Cook caught his long target for 9 yards. Hines caught his only opportunity for 4 yards. It'll be tough to like any of these RBs in the Week 15 matchup with the Dolphins.

The normally pass-favoring Bills leaned on the running game in Sunday's win over the Browns. RB Devin Singletary led the way, with 86 yards and the team's only rushing score on 18 carries. Rookie James Cook added 86 yards on 11 carries. Nyheim Hines barely factored in again, losing 8 yards on his lone carry and watching his lone target fall incomplete. Thanksgiving Day brings a Detroit defense that entered Sunday just 27th in Football Outsiders' run-defense DVOA.

Bills RB Devin Singletary chipped in 2 goal line TDs in Sunday’s loss to Minnesota. Singletary actually saw 4 total goal line carries — including 3 in the 1st quarter alone. It was a deviation from what we’ve seen this year, but perhaps Josh Allen’s injured elbow played a role. Singletary lost a close fumble and added only 1 catch (2 targets). Oddly, Buffalo also activated Duke Johnson, who mixed in for 2 carries behind James Cook (5 attempts). Nyheim Hines at least remained a total non-factor on offense with 1 touch. Singletary draws a favorable matchup with Cleveland in Week 11.

Bills RB Devin Singletary led the backfield with 8 carries (for just 24 yards) in Sunday's loss to the Jets and tied for 2nd on the team in targets (5). He caught 4 balls for 24 yards on a tough day for the passing offense. Rookie James Cook added 2 catches for 18 yards among 4 targets, plus a 4-15 rushing line. Nyheim Hines played just 3 offensive snaps and watched his lone target sail past him on a downfield route. Singletary dominated playing time, garnering 47 snaps to Cook's 14. We'd certainly bet on a playing-time increase for Hines as he gets more time in the offense.

The Bills are acquiring RB Nyheim Hines from the Colts, according to ESPN's Adam Schefter. The move continues Buffalo's pursuit of an upgrade at receiving back. The timing -- after a solid game from James Cook -- points to the Bills not believing the rookie is ready for a bigger role. Hines brings more proven NFL ability as a runner. He figures to challenge the playing time of RB Devin Singletary as well. It should be an upgrade in opportunity for Hines, who sits just 68th among RBs in opportunity share for his 2022 games with Indy. He garnered a stronger 11.8% target share in his 5 healthy games. Buffalo ranks 5th in the league in pass attempts but just 16th in RB receptions. We'll see whether that shifts at all with Hines around. Hines is signed through 2024 but has 2 cuttable years beyond this one. His arrival hurts the short-term outlook for Cook, though there's a chance Buffalo moves on from Hines after this year. The Bills are sending RB Zack Moss and a conditional 6th-round pick in the 2023 NFL Draft to the Colts. Moss has a chance to push past Deon Jackson on the Indy depth chart, but that's far from a sure thing.

Colts RB Jonathan Taylor rushed 16 times for 76 yards (4.8 per carry) in Sunday's loss to the Commanders. He left briefly with an ankle tweak but returned. RB Nyheim Hines carried 5 times for 20 yards and the team's lone TD. He added 2 catches for 29 yards. Deon Jackson took the remaining RB carry for a loss of 4. Next up: a Week 9 visit to New England. A road game at the Raiders follows.

Colts RB Jonathan Taylor carried just 10 times for 58 yards in Sunday's loss to the Titans, his return from a 2-game absence for an ankle sprain. Taylor added 7 catches for 27 yards on 8 targets, ranking 3rd on the team in that category. He ran just 3 more pass routes than Nyheim Hines for the game, according to Pro Football Focus, a significant change from Taylor's last time out. In that loss to Tennessee, Taylor ran 29 routes to Hines' 11. Hines added 5 receptions for 41 yards on 5 targets in Sunday's game and contributed just 2 rushing yards on 4 carries. Deon Jackson got 2 carries for 3 yards. Indy gets a challenging rushing matchup with Washington in Week 8 and then visits New England in Week 9.

Colts RB Jonathan Taylor (ankle) is not listed on the final injury report. He practiced all week, including full workouts on Thursday and Friday. HC Frank Reich confirmed on Friday that Taylor will resume handling the bulk of the backfield work vs. the Titans this weekend. RBs Nyheim Hines (concussion) and Deon Jackson (quad) are also off the final injury report but aren’t viable fantasy plays.

Colts RB Jonathan Taylor (ankle) remained limited on Wednesday. He got in limited practices last Thursday and Friday but missed the Jaguars game. We're guessing Taylor returns for this weekend's game vs. the Titans, but he's certainly not a lock. We'll get another update tomorrow. RBs Nyheim Hines (concussion) and Deon Jackson (quad) put in full practices on Wednesday and should be available this weekend.

Colts RB Deon Jackson was knocked out of Sunday's win over the Jaguars with a quad injury. He racked up 42 yards and a score on the ground plus 10 catches for 79 yards before exiting. Jackson's absence left Phillip Lindsay as Indianapolis' top RB. We'll see if Jackson, Jonathan Taylor and Nyheim Hines are available for Week 7

The Colts have downgraded RBs Jonathan Taylor (ankle) and Nyheim Hines (concussion) to out for Sunday's game against the Jaguars. That leaves Deon Jackson as the anticipated starter. He obviously lands in a good situation for touch upside. Jacksonville does rank 9th in Football Outsiders' run-defense DVOA and 7th in overall defensive DVOA, though. So it's not a terrific matchup. Consider Jackson to be a fantasy option if you're in need rather than a player to specifically target.

Colts RB Nyheim Hines (concussion) is listed as questionable for this weekend’s game vs. the Jaguars. He graduated to a full practice on Friday, so it looks like he has a good chance to be cleared by Sunday. Hines, of course, will only be a fantasy option if he plays and RB Jonathan Taylor doesn’t.

Colts RB Jonathan Taylor (ankle) returned to a limited practice on Thursday. We'll see how that ankle responds and what he's able to do on Friday. RB Nyheim Hines (concussion) remained limited on Thursday.

Colts RB Nyheim Hines (concussion) got in a limited practice on Wednesday. That means he's made progress through the protocol and has a chance to be cleared for Sunday's game vs. the Jaguars. We'll get another update on his status tomorrow.

Colts HC Frank Reich said after Thursday night's win over the Broncos that he's "optimistic" RB Jonathan Taylor (ankle) can return next week, per The Athletic's Zak Keefer. We'll keep an eye on Taylor's practice participation next week, as well as Nyheim Hines' after he sustained a concussion.

Colts RB Nyheim Hines sustained an apparent concussion on the 1st series of Thursday night's game vs. the Broncos. Hines stumbled as he tried to get off the field. So, after what happened recently with Dolphins QB Tua Tagovailoa, don't expect to see Hines back on the field tonight. That'll leave the Colts with RBs Phillip Lindsay and Deon Jackson.

Update: Hines has a concussion and is out for the rest of the game.