Colts RB Nyheim Hines (concussion) got in a limited practice on Wednesday. That means he's made progress through the protocol and has a chance to be cleared for Sunday's game vs. the Jaguars. We'll get another update on his status tomorrow.

Patriots RB Damien Harris (hamstring) was listed as a limited participant in Wednesday's practice. It's a surprise after NFL Network's Ian Rapoport said earlier this week that Harris is “likely to miss multiple games.” We still wouldn't plan on having him in Week 6 fantasy lineups, but we'll continue to keep tabs on his status leading up to Sunday's game vs. the Browns.

NFL Network’s Tom Pelissero tweeted Tuesday that Pats RB Damien Harris (hamstring) is “likely to miss multiple games.” Rhamondre Stevenson stepped up with 27 touches last Sunday against Detroit and will remain busy in Week 6 at Cleveland. The Browns field one of the league’s worst run defenses.

With Dawson Knox out, Quintin Morris worked as the starter and clear leader among Bills TEs in Sunday's win over the Steelers. He played 15 more snaps than #2 Tommy Sweeney and ran 17 more routes. Morris also claimed all 4 TE targets in the game. That's not a fantasy-relevant level of inclusion for most formats. We'll see whether Knox is ready to return for Week 6.

Bills WR Gabriel Davis had a big Sunday, thanks to TD catches of 98 and 62 yards in the win over the Steelers. He added 1 other reception, for a total of 171 yards and 2 TDs among 6 targets. That marked a 19.4% share of Josh Allen pass attempts. (QB Case Keenum then entered to close out the game.) Davis trailed only WR Stefon Diggs in that category, and matched Diggs' playing time. This looks like the level of usage we should expect from a healthy Davis. We'll see how the target share holds up once WR Isaiah McKenzie and TE Dawson Knox return from injuries.

Bills QB Josh Allen racked up 424 passing yards and 4 TDs in Sunday's lopsided home win over the Steelers. He hit WR Gabriel Davis for TDs of 98 and 62 yards. Allen also connected with WR Stefon Diggs and rookie WR Khalil Shakir for scores. Diggs drew 35.5% of Allen's pass attempts for the game as the only Bills player to exceed 6 targets. A potential shootout at Kansas City awaits in Week 6, with Buffalo's bye on the other side.

Rams S Taylor Rapp (ribs) is active for today's game against the Cowboys.

Patriots RB Damien Harris suffered a hamstring injury in the 1st half of Sunday's game vs. the Lions and is officially questionable to return. Rhamondre Stevenson is the only other available RB for New England. We'll update Harris' status when we know more.

Update: Harris has been ruled out.

Rams S Taylor Rapp (ribs) is questionable for Sunday's game against the Cowboys. He opened the week with 2 limited practices but then sat out Friday. We'll check his status Sunday.

The Bills have ruled S Jordan Poyer out for Sunday's game against the Steelers because of his rib injury. S Damar Hamlin started in place of S Micah Hyde last week and should remain in the lineup. We'll see who replaces Poyer, who didn't miss a snap in the Week 4 win over Baltimore. Jaquan Johnson started next to Hamlin in Week 3, when Buffalo last went without both starting safeties. He looks like the best bet to join Hamlin again. We'd try to look elsewhere for IDP options in most cases.

Bills TE Dawson Knox (foot, hamstring) is out for Sunday's game vs. the Steelers. He's been banged up all season, so the week off should be good for him. Knox's absence leaves Buffalo with TEs Quintin Morris and Tommy Sweeney. Morris is the better bet for targets but would be a desperation fantasy play.

Colts RB Nyheim Hines sustained an apparent concussion on the 1st series of Thursday night's game vs. the Broncos. Hines stumbled as he tried to get off the field. So, after what happened recently with Dolphins QB Tua Tagovailoa, don't expect to see Hines back on the field tonight. That'll leave the Colts with RBs Phillip Lindsay and Deon Jackson.

Update: Hines has a concussion and is out for the rest of the game.

As expected, Broncos RB Latavius Murray is a healthy scratch for tonight's game vs. the Colts. Expect him to make his Broncos debut next week. RB Devine Ozigbo was elevated from the practice squad today and is active. He figures to see most of his action on special teams. We're expecting RB Melvin Gordon to handle most of the backfield work, with RB Mike Boone mixing in.

Bills TE Dawson Knox (foot, hamstring) remained sidelined on Thursday. He appears to be in real danger of missing this weekend's game vs. the Steelers, but we'll get another update on his status tomorrow.

Broncos RB Latavius Murray won't play vs. the Colts tonight, according to NFL Network's Ian Rapoport. "Just too quick a turnaround from London and with a new system," Rapoport adds. "Expect him to play vs. the Chargers [next week]." So it'll be Melvin Gordon and Mike Boone in Denver's backfield tonight. NFL Network's James Palmer says Gordon will be the "bell cow." He's a solid RB2 play. Consider Boone a shaky RB3 or flex.

The Ravens signed WR Andy Isabella to the practice squad. Baltimore has 1 of the weakest depth charts in the league, so it's a fine landing spot for Isabella. But we have no faith in his ability to capitalize on the opportunity.

Bills TE Dawson Knox (foot, hamstring) did not practice on Wednesday. He played through back and hip injuries last week but is now dealing with 2 different ailments. We'll see if Knox is able to practice tomorrow.

Bills WR Gabriel Davis (ankle) was a full participant in Wednesday's practice -- his 1st full practice since suffering that ankle injury on September 17. Davis has played a full allotment of snaps the past 2 games but clearly hasn't been at 100%. It looks like he'll be in much better shape for this weekend's game vs. the Steelers.

The Cardinals released WR Andy Isabella. Despite plenty of opportunity early this season, the 2019 2nd-rounder caught just 2 of 5 targets over the season's first 4 weeks. We'll see if he lands a job elsewhere, but Isabella looks like a big-time bust.

Patriots RB Damien Harris led the backfield in carries (18) and rushing yards (86) in Sunday's OT loss at Green Bay. That included claiming the team's only rushing score. Rhamondre Stevenson ran for 66 yards on 14 carries but also led the team in targets (5) and receptions (4). Stevenson's passing-game usage again found him leading Harris in snaps.