Saints RB Devin Neal (hamstring) is out for Sunday's game vs. the Jets, HC Kellen Moore said Wednesday. Don't be surprised if the rookie is done for the season with what seems like a relatively significant hamstring injury. RB Alvin Kamara (knee, ankle) remained sidelined on Wednesday and looks likely to miss another game. That'd leave New Orleans' backfield to Audric Estime and Evan Hull vs. the Jets this weekend. The team also signed RB Nyheim Hines to the practice squad on Wednesday. This is a backfield to avoid in Week 16 fantasy lineups.

Chargers HC Jim Harbaugh labeled RB Hassan Haskins doubtful for Thursday night's game vs. the Vikings due to a hamstring injury. Haskins has been vastly out-played by RB Kimani Vidal over the last two weeks, but he's still siphoned seven carries and three targets. His absence will leave Nyheim Hines as the Chargers' No. 2 RB, but we could see Vidal pick up more work. He's a solid RB2 in fantasy lineups in this week with six teams on bye.

Chargers RB Omarion Hampton (ankle) is out at least the next four weeks on IR. But NFL Network's Mike Garafolo hears that the rookie will "likely" miss more time than that. "It's not a season-ending injury," Garafolo adds. The Chargers have a bye in Week 12 (six weeks from now), so it's possible that we don't see Hampton again until Week 13. Garafolo also reports that the Chargers have been calling around about potential trades for a RB. We'll see where that goes. And we'll see what this backfield looks like today with Hassan Haskins, Kimani Vidal, and Nyheim Hines.

The Chargers are signing RB Nyheim Hines to their practice squad. Hines hasn't played a regular-season snap since suffering a knee injury in a jet ski accident in 2023. He turns 29 next week. And, even before that injury, he was just a change-of-pace back, never topping 89 carries in an NFL season. The Chargers, of course, are without RB Omarion Hampton for at least the next four games -- after losing RB Najee Harris for the season. Hassan Haskins and Kimani Vidal lead the most uninspiring RB room in the league. Hines was with the Chargers during training camp this season, but we'd still consider him a long shot to make a fantasy impact. He can stay on the waiver wire. If the Chargers are done adding to their backfield, it'd be good news for the upside on Haskins and Vidal.

Browns RB D'Onta Foreman was back on the field for Thursday's practice, according to insider Tony Grossi. Foreman was taken to the hospital with back and neck injuries just a week ago but has evidently been cleared to return in some capacity.

The Browns and RB Nick Chubb have agreed to a salary adjustment for 2024, the final year on his contract. ESPN's Jeremy Fowler reports that the change drops Chubb's cap hit from $15.85 million to $6.275 million -- with incentives that could bring his salary back up to $12.2 million. You could read this several different ways. It's positive that Cleveland didn't simply cut Chubb, which would have cost just $4 million in dead cap space, according to Spotrac. But Chubb's new salary knocks him to 11th among RBs in total money for 2024, behind Tony Pollard and Aaron Jones; barely ahead of Devin Singletary and Miles Sanders. Chubb no doubt believes he can achieve at least some of the performance incentives and drive that number back up. But it also appears he wasn't willing to test the open market for higher 2024 earnings. Ultimately, it's way too early for fantasy managers to know what we can expect from the veteran RB. Chubb's multi-ligament knee injury in September has required surgeries then and in November. We haven't seen much on his return timeline. The Browns, meanwhile, have added RBs D'Onta Foreman and Nyheim Hines this offseason. Both signed small, one-year deals that don't come close to guaranteeing offensive roles. (Hines probably arrives to primarily return kicks.) But they join Jerome Ford and Pierre Strong as backfield insurance. We're staying away from Chubb at his RB27 best ball ADP, which still has him ahead of Javonte Williams, Austin Ekeler, and Zamir White, among others. The crowded depth chart behind Chubb also makes it a risky backfield for investing in backups.

Bills RB Nyheim Hines is expected to miss the entire 2023 season after suffering a "significant knee injury off-site," according to NFL Network's Tom Pelissero. We'll look for more details on the injury and Hines' rehab timeline. The Bills acquired him via trade last November but used him primarily in a special teams role. Hines handled just six carries and nine targets in nine regular season games -- and then zero carries and three targets in two postseason appearances. There's very little fantasy impact here, besides making RB James Cook a slightly safer bet to handle passing-down snaps.

Update: Pelissero reports that Hines was struck by a jetski. He suffered a torn left ACL, per team reporter Alaina Getzenberg.

Colts RB Jonathan Taylor (ankle) is not listed on the final injury report. He practiced all week, including full workouts on Thursday and Friday. HC Frank Reich confirmed on Friday that Taylor will resume handling the bulk of the backfield work vs. the Titans this weekend. RBs Nyheim Hines (concussion) and Deon Jackson (quad) are also off the final injury report but aren’t viable fantasy plays.

Colts RB Deon Jackson was knocked out of Sunday's win over the Jaguars with a quad injury. He racked up 42 yards and a score on the ground plus 10 catches for 79 yards before exiting. Jackson's absence left Phillip Lindsay as Indianapolis' top RB. We'll see if Jackson, Jonathan Taylor and Nyheim Hines are available for Week 7

Colts RB Jonathan Taylor (ankle) has been ruled out for Thursday night's game vs. the Broncos. He was always a long shot to play on the short week. Taylor's injury reportedly isn't serious, so he should have a shot to return for Week 6. JT's absence in Denver will leave the Colts with RBs Nyheim Hines, Deon Jackson and Phillip Lindsay, who's expected to be elevated from the practice squad. When Taylor missed Week 12 of the 2020 season, Hines played 65% of the offensive snaps and handled 10 carries and 10 targets.

Colts RB Jonathan Taylor left in the 2nd quarter of Thursday night's game against the Jets with a knee injury. Indianapolis reached halftime with a 28-10 lead, so we wouldn't be surprised if the team shuts Taylor down for the night -- even if the injury isn't serious. We'll keep an eye on the situation either way.

Update: Taylor took the field to open the 2nd half.

Colts HC Frank Reich said Tuesday that G Quenton Nelson has the same foot injury as QB Carson Wentz, according to multiple reports. He's having surgery immediately and faces the same return window (5-12 weeks) as Wentz. That's bad news for Jonathan Taylor and everyone else who lines up in the Indy backfield. We'll see exactly how long Nelson (and Wentz) remains out.