49ers WR Brandon Aiyuk (shoulder) was limited in Wednesday's practice. He was seemingly close to playing last Thursday night, so we're tentatively expecting him back for this weekend's game vs. the Cardinals.

49ers WR Deebo Samuel (ribs, knee) did not practice on Wednesday. He hurt his ribs in last Thursday night's win over the Giants but was labeled "day-to-day" by HC Kyle Shanahan. We don't have any info on the knee issue. We'll see if Samuel gets back on the practice field tomorrow.

49ers WR Deebo Samuel is "day-to-day" with a rib injury suffered in Thursday night's game vs. the Giants, HC Kyle Shanahan said. Samuel returned after suffering the injury, scoring a 29-yard TD in the fourth quarter. He should be fine for Week 4, especially with the extra few days to rest up.

49ers TE George Kittle totaled just six catches for 49 yards over the first two games of the season. He topped both of those marks in Thursday night's win over the Giants, hauling in seven balls for 90 yards. The big difference? San Francisco was without WR Brandon Aiyuk. Kittle drew nine targets for a 24.3% share vs. New York -- well up from his 16.7% target share over the first two weeks of the season. Kittle is an elite fantasy option whenever Aiyuk, WR Deebo Samuel, or RB Christian McCaffrey are out. He'll be inconsistent when all three of those guys are healthy. We'll see if Aiyuk is able to make it back for Week 4.

With WR Brandon Aiyuk inactive with a shoulder injury, 49ers WR Deebo Samuel was featured in Thursday night's win over the Giants. He drew a team-high 12 targets for a 32.4% target share. Samuel and QB Brock Purdy actually missed on a few connections they usually make, but Samuel still finished with 6 catches for 129 yards and a score. He had a couple of trademark bulldozing catch-and-runs. And he capped the night with a 29-yard TD down the right sideline. Expect Samuel's target share to take a bit of a hit whenever Aiyuk is ready to return. But he'll remain a big part of this high-scoring 49ers offense -- and a strong WR2 in fantasy lineups.

49ers RB Christian McCaffrey's four-yard TD run in the second quarter of Thursday night's win over the Giants marked his 12th straight game with at least one TD. That ties WR Jerry Rice for the longest streak in franchise history. McCaffrey finished this one with 18 carries for 85 yards and the score, plus five catches on five targets for 34 yards. He gave way to RB Elijah Mitchell a bit more in this one -- but fantasy owners have nothing to complain about. McCaffrey will continue to be an elite fantasy asset as long as he stays healthy. He gets another plus matchup in Week 4 vs. the Cardinals before tougher draws against the Cowboys and Browns.

49ers QB Brock Purdy was without WR Brandon Aiyuk on Thursday night but still delivered a strong fantasy outing in the win over the Giants. He completed 25 of 37 passes (67.6%) for 310 yards (8.4 YPA), two TDs, and 0 INTs. Purdy actually missed a few throws early on but settled in by the second quarter. He found WR Ronnie Bell at the front pylon for a nine-yard score in the second quarter and then tossed a beautiful back-shoulder deep ball to WR Deebo Samuel for a 27-yard score in the fourth. Purdy has now tallied multiple passing TDs in nine of his 11 full games as a pro. He gets another plum matchup in Week 4 vs. the Cardinals that will make him a viable QB1. That's followed by much tougher draws vs. the Cowboys and Browns.

49ers WR Brandon Aiyuk (shoulder) is officially inactive for tonight's game vs. the Giants. He seemed relatively close to playing tonight, so we're tentatively expecting him back for Week 4. Aiyuk's absence should make San Francisco's offense even more concentrated, with RB Christian McCaffrey, WR Deebo Samuel, and TE George Kittle dominating touches.

The 49ers have downgraded WR Brandon Aiyuk to out for tonight's game against the Giants because of his shoulder injury. That should make Jauan Jennings the No. 2 WR for the upside matchup. Aiyuk (14) and Deebo Samuel (16) have accounted for 88.2% of WR targets for San Francisco through two weeks, with Jennings claiming the only other four. Jennings posted three games of 4+ receptions last year, though none came with Brock Purdy behind center. Jennings makes for a nice play in Thursday night DFS showdowns. He's too much of a longshot for most season-long redraft formats, though. Seventh-round rookie Ronnie Bell has been the No. 4 WR in playing time so far and matched Jennings in snaps in Week 2. He has yet to see a target, though.

The 49ers list WR Brandon Aiyuk (shoulder) as questionable for Thursday night's game against the Giants. ESPN's Nick Wagoner reports that HC Kyle Shanahan "indicated" Aiyuk will be a game-time decision. Fortunately, it's the first game of the week. So we'll know more before you're setting your Week 3 lineups.

49ers WR Brandon Aiyuk (shoulder) will be a game-time decision for Thursday night's meeting with the Giants, HC Kyle Shanahan said Tuesday. Aiyuk was limited in Tuesday's practice. We'll continue to look for updates on his status, but it seems like he'll come with elevated risk in Week 3 fantasy lineups if he does suit up on Thursday night.

A CT scan on 49ers WR Brandon Aiyuk's clavicle came back clean, according to The Santa Rosa Press Democrat's Jack Hammer. "His ability to play Thursday night will be all about pain tolerance," Hammer adds. We'll keep an eye on Aiyuk's status and will get San Francisco's inactives around 7 pm ET on Thursday.

49ers WR Brandon Aiyuk injured his left shoulder on the opening drive of Sunday's win over the Rams. He eventually returned to the game but ended up playing just 53% of the offensive snaps. HC Kyle Shanahan on Monday wouldn't commit to Aiyuk being available for Thursday night's game vs. the Giants. We're tentatively expecting Aiyuk to be out there for that one, but we'll watch his status over the next few days.

The 49ers have given RB Christian McCaffrey 2 more carries through two weeks than any other player in the NFL has received. His 42 rushes lead Derrick Henry (40) and Tony Pollard (39), with the two Monday night games of Week 2 yet to go. That's abnormal for McCaffrey, who has reached 20 carries in consecutive games just three other times in his career. He averaged 14.7 carries per game across 13 starts with the 49ers last year, including the playoffs. Summer indications had San Francisco planning to use McCaffrey in a way that would preserve him for the season. That doesn't match up with 21.0 carries per game, of course. We'd be surprised if his carry count and carry share stays that high. But it doesn't really matter as long as McCaffrey stays healthy. He's obviously an every-week starter whenever available. No other 49ers RB even played an offensive snap against the Rams.

Niners LB Dre Greenlaw opened the week missing practice with a groin injury. But he returned for a limited Thursday workout and participated fully on Friday. The 49ers left him off the final injury report, indicating that Greenlaw is ready for Sunday's game against the Rams without restriction.

Niners LB Dre Greenlaw missed practice Wednesday with a groin injury. We'll see how he fares the next two days, ahead of Sunday's meeting with the Rams.

49ers WR Brandon Aiyuk exploded in Week 1 vs. the Steelers, hauling in all 8 targets for 129 receiving yards and 2 TDs. Teammate Deebo Samuel logged 5 catches on 7 targets for 55 of his own, and yards TE George Kittle had a quiet contest with just 3 catches on 6 targets for 19 yards. Despite the best efforts of Steelers CB Patrick Peterson, Aiyuk could not be stopped en route to setting a new career-high in yards in Sunday’s win. As a whole, the 49ers’ offense fired on all cylinders. Next week, the 49ers will face off against the Rams, a division opponent they beat in both of their matchups last season.

49ers RB Christian McCaffrey recorded 22 attempts for 152 rushing yards, including a 65-yard TD in Week 1’s win vs. the Steelers. He also added 3 receptions on 7 targets with 17 receiving yards through the air. The Pittsburgh front struggled to stop McCaffrey for the majority of the contest. His 25.9 PPR points are a strong contender to be the most among RBs in Week 1. Fantasy managers should expect another robust outing in Week 2 vs. the Rams.

49ers QB Brock Purdy completed 19 passes on 29 attempts for 220 passing yards with 2 TDs and zero INTs in Sunday’s win vs. the Steelers. The second-year signal-caller also added a career-best 20 rushing yards on 3 carries in the contest. The 49ers recorded 391 yards of total offense, the highest of any team in the early slate of games. Aside from a strip sack by Steelers LB T.J. Watt, Purdy performed efficiently and should have another solid outing in Week 2 vs. the Rams.

49ers TE George Kittle (groin) is active for today’s game vs. the Steelers. He was limited in practice all week, but we’ve heard nothing to suggest that he’ll be limited today. Considering the league-wide issues at TE, Kittle belongs in Week 1 fantasy lineups.