49ers WR Ricky Pearsall (knee, ankle) got in a limited practice on Wednesday. That gives him a shot to return for Sunday night's game vs. the Bears. Pearsall would be a risky fantasy play coming off an aggravation of his PCL injury, although TE George Kittle's absence would make him more enticing. We'll keep you updated on Pearsall's status over the next few days.

49ers TE George Kittle (ankle) did not practice on Wednesday. “He’s got a chance, so we’re not ruling him out," HC Kyle Shanahan said. We'll hopefully have a good idea of Kittle's status for the Bears game by Sunday morning, but we won't get San Francisco's inactives until a little before 7 pm ET. Fantasy managers hoping to start Kittle should stash TE Jake Tonges as insurance.

49ers TE George Kittle suffered a “mid-to-low ankle sprain" in Monday night's win over the Colts, according to ESPN's Jeremy Fowler. That's better news than a high-ankle sprain but still leaves Kittle uncertain for Sunday night's game against the Bears. We'll keep tabs on his status throughout the rest of the week. Kittle's absence would turn TE Jake Tonges into an intriguing spot starter. He averaged 6.2 targets, 4.4 catches, 41.8 yards, and 0.4 TDs in the five games Kittle missed early this season.

49ers QB Brock Purdy went 25/34 for 295 yards and 5 TDs with RB Christian McCaffrey going 21-117-0 on the ground and 6-29-2 on 8 targets through the air. The 49ers team put up 48 points on the Colts with Purdy tossing every TD except a late fourth-quarter pick-six from the defense. The 49ers' offense helped elevate playoff fantasy teams to make comebacks and could be league winners next week against the Bears.

49ers TE George Kittle hurt his left ankle in the third quarter of Monday night's game vs. the Colts. He was visibly frustrated as he made his way off the field. Kittle was deemed questionable to return and remained on the sidelines, but he never made it back onto the field. He had a monster game before exiting, catching 7 of 8 targets for 115 yards and a score. But his availability for Sunday night's game vs. the Bears is now uncertain. HC Kyle Shanahan didn't have an update on the injury afterward. We'll keep you posted.

49ers WR Ricky Pearsall (ankle, knee) is out for Monday night's game vs. the Colts. He didn't practice all week and could certainly miss multiple games after aggravating his PCL injury last week. Pearsall's absence boosts the target projections on WR Jauan Jennings and TE George Kittle.

49ers WR Ricky Pearsall (ankle, knee) did not practice on Thursday. He played through the ankle issue last weekend, but the knee -- an aggravation of his previous PCL injury -- knocked him out of the Titans game. We're not expecting Pearsall to play vs. the Colts on Monday night but will keep you updated on his status.

49ers WR Ricky Pearsall is iffy for next Monday night's game vs. the Colts after suffering ankle and knee injuries in the Week 15 win over the Titans, HC Kyle Shanahan said Monday. Pearsall was able to return after hurting an ankle on a hip-drop tackle in the first quarter, but a knee injury in the fourth knocked him out. Shanahan said that it's an aggravation of the PCL injury that cost Pearsall six games earlier this season. "It's real painful for awhile, but it can go away," Shanahan said. "Not at all like it was when he first did it, but it does take time for that pain to go away. Hopefully sooner than later." We'll keep you updated on Pearsall's status throughout the week, but fantasy owners should not be banking on him playing against the Colts.

Niners WR Ricky Pearsall limped off the field in the first quarter after a hip-drop tackle by Titans S Kevin Winston on his first reception. He was pretty clearly favoring his left knee but remained on the sideline. We'll see about his status as the game progresses. It's at least the opposite knee from the one in which he suffered his early-season PCL injury.

Update: Pearsall returned before the end of the quarter.

49ers RB Christian McCaffrey (back) is active for today’s game vs. the Titans. He was added to the injury report as questionable on Saturday, but ESPN’s Adam Schefter reported a short time later that McCaffrey would be “good to go” for this one. We haven’t heard anything about his snaps or touches being limited today. McCaffrey remains a must-start.

The 49ers officially put an end to WR Brandon Aiyuk's season on Saturday, placing him on the reserve/left squad list. Aiyuk has not played since suffering a multi-ligament knee injury in Week 7 of the 2024 season. It's unclear exactly where he's at in his rehab, but Aiyuk never seemed likely to play this year after we learned the team voided the more than $25 million guaranteed for 2026 in his contract. Aiyuk is expected to be released this offseason and figures to draw plenty of interest. He turns 28 in March and has averaged 62 receiving yards per game for his career.

49ers RB Christian McCaffrey (back) is "expected to be good to go" for tomorrow's game vs. the Titans, ESPN's Adam Scheft reports. Exhale! We'll look for further updates on McCaffrey's status, but he can stay penciled into Week 15 fantasy lineups for now.

49ers RB Christian McCaffrey has been added to the injury report with a back issue and is now questionable for Sunday's game vs. the Titans. We don't have any other details at this point. McCaffrey has no noted history of back trouble. We'll of course keep you updated on his status. But RB Brian Robinson would turn into a strong fantasy play if McCaffrey misses tomorrow's game and needs to be rostered in all fantasy leagues.

In this third game since returning from a 7-week layoff, San Francisco 49ers' WR had another forgettable fantasy showing in Cleveland. Pearsall caught 2 of his 3 targets for just 13 yards and failed to find the end zone. Since he's been back in the lineup, Pearsall has been held to 0, 6, and 13 receiving yards in three games.

The forecast for today's 49ers-Browns game calls for sustained winds of 25 mph with gusts around 35 mph. The total in this game has dropped from 42.5 to 35.5. Expect a run-heavy game plan from both sides. RBs Christian McCaffrey and Quinshon Judkins can stay in fantasy lineups. TE George Kittle is the only comfortable play from either passing game. Avoid the kickers.

49ers K Eddy Pineiro (hamstring) is out for Sunday’s game vs. the Browns. Matt Gay will kick again for San Francisco but isn’t a recommended fantasy play in what’s expected to be bad weather in Cleveland.

49ers K Eddy Pineiro (hamstring) is out for Monday night's game vs. the Panthers. He'll be replaced by K Matt Gay, who made just 13 of 19 FGs for Washington across 10 games this season. Look elsewhere for your Week 12 fantasy kicker.

The 49ers have voided the more than $25 million guaranteed for 2026 in WR Brandon Aiyuk's contract, according to The Athletic. Aiyuk reportedly skipped meetings and other activities in recent months, as he's continued to work back from his October 2024 knee injury. Aiyuk will not be contesting the voided money. There have been "repeated overtures from team officials and even players to try to bring Aiyuk back into the fold," per The Athletic. But "it’s now likely that the 27-year-old has played his last game with the franchise." Aiyuk is expected to be released after the season.

Niners LB Tatum Bethune suffered a high-ankle sprain in Sunday's win over the Cardinals. HC Kyle Shanahan said Monday that they expect Bethune to miss multiple weeks but that he probably won't hit IR because of the Week 14 bye.

Niners WR Ricky Pearsall managed just 1 catch for no yards among three targets in his return Sunday from a seven-week absence for a knee injury. But the outing was more encouraging than that would suggest.