49ers TE George Kittle (groin) remained limited in Thursday's practice. We're tentatively expecting him to make his 2022 debut against the Broncos on Sunday night, but check back tomorrow for another update.

Panthers RB Christian McCaffrey was added to Thursday's injury report and limited in practice with an ankle. According to Darin Gantt of the team's official website, McCaffrey "had some stiffness" in the ankle but is still expected to play vs. the Saints on Sunday. We'll look for further updates on McCaffrey's status and will get another practice report tomorrow.

49ers TE George Kittle (groin) was limited in Wednesday's practice. He returned to a limited practice last Friday before missing the Seahawks game, but it seems like he has a legitimate chance to play vs. the Broncos on Sunday night. We'll have another update tomorrow.

49ers RB Ty Davis-Price suffered a high-ankle sprain in Sunday's win over the Seahawks, HC Kyle Shanahan said. That injury typically costs guys 4-6 weeks. Davis-Price handled 14 carries behind RB Jeff Wilson's 18 in Week 2. San Francisco is now down to RBs Jordan Mason and Marlon Mack behind Wilson. Mason has been active the first 2 weeks but has yet to play an offensive snap. Mack couldn't make Houston's final roster. Wilson has a good chance to control backfield work until RB Elijah Mitchell returns from his knee injury.

Panthers RB Christian McCaffrey posted 128 scoreless yards in a Week 2 loss to the Giants. As usual, CMC rarely left the field, ultimately seeing a 91% snap share ahead of D’Onta Foreman (5%) and Chuba Hubbard (3%). The backups combined for only 2 touches. Our biggest concerns going forward are a hot-and-cold Baker Mayfield and a Matt Rhule-led Panthers squad that ranks 28th in total offense. High touch volume still keeps CMC in the top-3 discussion.

49ers TE George Kittle (groin) is inactive for today’s game vs. the Seahawks. He returned to a limited practice on Friday, so it seems like he at least has a good shot to be back for Week 3. Kittle’s absence is a downgrade from QB Trey Lance but boosts the target projections for WRs Deebo Samuel and Brandon Aiyuk.

ESPN's Adam Schefter reports that 49ers TE George Kittle (groin) is not expected to play vs. the Seahawks today. NFL Network's Ian Rapoport, meanwhile, is leaving the door open for Kittle to play. He says Kittle will be a game-time decision and is "pushing to play." But Rapoport also says Kittle's injury was originally expected to cost him 3 weeks. There's a good chance that Kittle will be limited even if he does suit up today. We won't get the 49ers' inactives until a little after 3:30 pm ET.

49ers TE George Kittle (groin) is listed as questionable for this weekend's game vs. the Seahawks after returning to a limited practice on Friday. “He looked awesome," HC Kyle Shanahan said afterward, adding that Kittle will be a game-time decision. This is a 4:05 pm ET kickoff, which might put Kittle owners in a tough spot. We'll see if we get an update on his status on Sunday morning.

49ers TE George Kittle (groin) remained sidelined on Thursday. He's looking like a long shot to play vs. the Seahawks this weekend. That's bad news for QB Trey Lance but good news for Deebo Samuel and Brandon Aiyuk's volume.

Niners LB Dre Greenlaw missed Wednesday's practice with an elbow injury. If he can't go Sunday against the Seahawks, then LB Azeez Al-Shaair would likely pick up starter-level snaps.

49ers TE George Kittle (groin) remained sidelined for Wednesday's practice. That's not a good start for his chances of returning for Sunday's game vs. the Seahawks. We'll see if Kittle is able to do anything on Thursday.

ESPN's Adam Schefter reports that 49ers RB Elijah Mitchell is expected to miss "about 2 months" with the MCL sprain he suffered in Sunday's loss at Chicago. Jeff Wilson Jr. stepped in after Mitchell left the game, though WR Deebo Samuel nearly matched his carry total (9-8). We'd bet on Samuel remaining significantly involved in the run game, which isn't great for his chances of staying healthy. We'd also expect rookie Tyrion Davis-Price to be activated for Week 2, after being a healthy scratch in the opener. RB Jordan Mason was active ahead of him but didn't play a snap on offense. Wilson is the only 49ers RB worth considering for Week 2 use. Don't expect him to land high in our Week 2 rankings when they hit the site Tuesday, however.

49ers RB Elijah Mitchell is expected to miss "a few weeks (or more)" with the knee injury he suffered in Sunday's opener vs. the Bears, per NFL Network's Ian Rapoport. Mitchell is undergoing an MRI on Monday to get a full view of the damage to the knee. We should get a more concrete timeline for his return over the next couple days, but fantasy owners need to start making replacement plans. Jeff Wilson is the favorite to take over as San Francisco's lead RB, but Jordan Mason and Ty Davis-Price are also worth stashing.

Niners WR Deebo Samuel fulfilled the Deebo Samuel role in Sunday's opening loss to the Bears. He drew a team-high 8 targets but caught just 2 for 14 yards in rain-drenched conditions. Samuel added 52 yards and a TD on 8 carries, trailing only QB Trey Lance among 49ers in rushing yards. We certainly can't count on rushing scores every week for Samuel, but the target count to go with the rushing work is encouraging. That's what lacked in the 2nd half of last year, when he was getting more handoffs than passing looks. Brandon Aiyuk drew just 2 target against the Bears, catching both for 40 yards. WR Jauan Jennings posted team highs of 4 receptions and 62 yards on 6 targets.

Panthers RB Christian McCaffrey ran for 33 yards and a score on 10 carries in Sunday's loss to the Browns, adding 4-24 receiving on 4 targets. A largely sluggish offensive day for Carolina hurt, and QB Baker Mayfield claimed a rushing TD from 7 yards out in the 4th quarter. D'Onta Foreman and Chubb Hubbard combined for just 3 carries and 0 targets behind him.

The 49ers have declared RB Elijah Mitchell out for the rest of today's game with a right-knee injury. We'll see about the severity.

49ers RB Tyrion Davis-Price is a healthy scratch for today's opener vs. the Bears. Shades of Trey Sermon last year! -- although this one isn't nearly as big a surprise. San Francisco will roll with RBs Jeff Wilson and Jordan Mason behind starter Elijah Mitchell.

49ers TE George Kittle (groin) is officially inactive for today’s opener vs. the Bears. He suffered what’s been reported as a Grade 2 groin strain on Monday and didn’t practice the rest of the week. We’ll see if Kittle can make it back for Week 2. His absence is a significant loss for QB Trey Lance but frees up targets for WRs Deebo Samuel and Brandon Aiyuk.

49ers TE George Kittle (groin) is "not likely" to play vs. the Bears today, according to NFL Network's Ian Rapoport. Kittle didn't practice after injuring his groin on Monday. "Pushing it early doesn't make sense," Rapoport tweets. We'll see if Kittle can make it back for Week 2. His absence is a significant loss for QB Trey Lance but frees up targets for WRs Deebo Samuel and Brandon Aiyuk.

49ers insider Eric Branch confirms that TE George Kittle (groin) is not expected to play vs. the Bears on Sunday. Kittle is listed as questionable but didn't practice all week after hurting his groin on Monday. Kittle should be on fantasy benches at this point. We'll see if we hear anything different on his Week 1 status.