49ers WR Richie James (ankle) is active for tonight's game against the Packers. So it'll be James, Trent Taylor, Kevin White and River Cracraft at WR for San Francisco. Taylor is the best bet of the bunch but is just a low-upside WR3.

The 49ers have added WR Brandon Aiyuk and LT Trent Williams to the COVID list. That means the offense will be missing both starters, in addition to Deebo Samuel (hamstring) and Kendrick Bourne (COVID). Those absences, of course, join RBs Raheem Mostert, Tevin Coleman and Jeff Wilson, as well as QB Jimmy Garoppolo and TE George Kittle. Trent Taylor suddenly looks like the team's top receiver ... and he might need to play a few more positions by the time we get to Thursday night. The NFL reportedly still plans to play the game at the scheduled time, though.

The 49ers on Wednesday received a positive COVID test and immediately closed team facilities. That's particularly noteworthy because it comes a day before San Francisco is scheduled to host the Packers on Thursday night football. We'll see whether this situation alters the timing of the game. If the NFL pushes the game to later in the weekend or Monday night, then Packers RB Jamaal Williams might have time to return from isolation. If the game remains on Thursday night, Williams will miss it because of close contact with RB AJ Dillon, who tested positive for COVID at the beginning of the week. More time also might help Aaron Jones move beyond his calf strain to play after missing the past 2 games. Stay tuned.

ESPN's Adam Schefter reports that 49ers QB Jimmy Garoppolo is expected to miss at least the next 6 weeks with what has been deemed a high-ankle injury. The QB could remain out even longer if his injury winds up requiring surgery, according to Schefter. Garoppolo obviously doesn't belong on any redraft fantasy football rosters during this span. QB Nick Mullens is in play for deeper leagues, including 2-QB and superflex formats. We'll see, though, whether he can hold the job. C.J. Beathard relieved Mullens in the Week 4 loss to Philadelphia and then Garoppolo in the following week's loss to the Dolphins.

Niners TE George Kittle will miss the next 8 weeks with a broken bone in his foot, according to ESPN's Adam Schefter. That basically puts him out for the rest of the fantasy football season. TE Jordan Reed (MCL) is eligible to return from IR, but the team didn't activate him ahead of Sunday's loss to the Seahawks. HC Kyle Shanahan said late last week that he hoped to get Reed back for the Week 9 game against the Packers. If Reed remains out, Ross Dwelley would operate as San Francisco's lead TE.

X-rays on 49ers TE George Kittle's ankle came back clean, HC Kyle Shanahan said after the loss to Seattle. Kittle is scheduled for more testing tomorrow. We should learn more about his injury within the next 24 hours. Kittle and the 'Niners have a short turnaround for Thursday night's game vs. the Packers.

49ers TE George Kittle suffered an ankle injury in the 4th quarter of Sunday's game against the Seahawks. He headed back to the locker room with trainers and is officially questionable to return. Stay tuned for an update.

49ers QB Jimmy Garoppolo was pulled in the 4th quarter of Sunday's game against the Seahawks. He appeared to tweak his knee or ankle taking a sack on his final snap and headed back to the locker room with trainers. Garoppolo was horrible before exiting, throwing for 84 yards, 0 TDs and 1 INT against a leaky Seattle defense. We'll see if Garoppolo is healthy enough to start Thursday night's game vs. the Packers -- and if San Francisco sticks with him.

Update: The 49ers announced Garoppolo with an ankle injury.

Niners S Jimmie Ward (quad) is active for today's game against the Seahawks. He'll take his position back from Tarvarius Moore and carries upside against pass-heavy Seattle.

The 49ers have deemed S Jaquiski Tartt (groin) and LB Kwon Alexander (ankle) doubtful for Sunday's game against the Seahawks. That should keep S Marcell Harris and LB Dre Greenlaw in full-time roles and in play for IDP lineups. S Jimmie Ward (quad) is questionable after missing last week's game. If Ward can't go, then Tarvarius Moore would get another start. We'll check his status Sunday.

49ers WR Deebo Samuel (hamstring) is out for Week 8. That leaves Brandon Aiyuk and Kendrick Bourne as San Francisco’s top 2 WRs vs. Seattle’s league-worst WR defense.

Niners S Jaquiski Tartt (groin) and S Jimmie Ward (quad) remained out of practice Wednesday after missing Sunday's win over the Patriots. Tarvarius Moore and Marcell Harris started in their places against New England and tied for the team lead with 5 solo tackles. Each would be in play for IDP use against a pass-heavy Seattle team this week if Tartt and Ward sit again. Moore is the Ward replacement and Harris for Tartt, though their in-game roles have been fairly interchangeable. Elsewhere on the defense, LB Kwon Alexander (high-ankle sprain) remained out of practice Wednesday. His absence would keep Dre Greenlaw in a full-time role.

49ers HC Kyle Shanahan said Monday that WR Deebo Samuel (hamstring) won't play against the Seahawks this weekend and will "probably" miss the following Thursday night's game vs. the Packers. It's worth noting that San Francisco has a Week 11 bye, so it's possible Samuel is held out of Week 10, too. His absence will leave rookie Brandon Aiyuk and Kendrick Bourne as the 49ers' top 2 WRs. That's especially important with Seattle's league-worst WR defense on tap.

The 49ers placed RB Jeff Wilson on IR with his high-ankle sprain. He's out for at least the next 3 games. RB Raheem Mostert (ankle) is out for at least 2 more games, while RB Tevin Coleman (knee) remains iffy for Sunday's tilt against the Seahawks. San Francisco might be down to RBs JaMycal Hasty and Jerick McKinnon for that one. Hasty should be owned in pretty much all fantasy leagues at this point.

Cam Inman of the San Jose Mercury reports that 49ers RB Jeff Wilson Jr. suffered a high-ankle sprain in Sunday's win over the Patriots. We'll see about the expected return timeline, but this likely makes Wilson a drop in nearly all redraft leagues. RB Tevin Coleman should return soon and faces big opportunity when he does make it back. If Coleman's not ready for Week 8, then rookie JaMycal Hasty figures to see an uptick in work. He logged 9 carries each of the past 2 weeks.

Niners WR Deebo Samuel left Sunday's game at New England with a hamstring injury and did not return. We'll watch for updates on his status heading into Week 8.

Update: It's a hamstring strain, according to Cam Inman of the San Jose Mercury. The team expects Samuel to miss at least Week 8 against Seattle. We'll see beyond that.

49ers RB Jeff Wilson suffered a lower left leg injury at the end of his 3rd TD run in Sunday's game against the Patriots. He got off the field under his own power but was carted to the locker room. We'll update Wilson's status when we know more.

Update: Wilson has an ankle injury and has been ruled out.

49ers RB Jeff Wilson (calf) is active for today’s game against the Patriots. He joins Jerick McKinnon and JaMycal Hasty in a backfield missing Raheem Mostert and Tevin Coleman. McKinnon is the best fantasy bet today, but this could be a “hot-hand” situation.

49ers RB Jeff Wilson (calf) is expected to play against the Patriots today, according to ESPN's Adam Schefter. He'll join Jerick McKinnon and JaMycal Hasty in San Francisco's backfield. Wilson isn't a bankable fantasy play but could handle goal-line work for the 'Niners today.

Panthers K Joey Slye has been activated from the COVID list and will kick against the Saints on Sunday. He's not a recommended fantasy play with Carolina 7.5-point underdogs in that one.