49ers WR Kendrick Bourne has returned 2 consecutive negative COVID tests, according to NFL Network's Mike Garafolo. Bourne, Brandon Aiyuk, Deebo Samuel and Trent Williams can re-join the team immediately. It's a tough break that all 4 guys were forced to miss Thursday night's loss to the Packers, but they'll be eligible to play Week 10.

ESPN's Adam Schefter reports that 49ers WR Kendrick Bourne has tested positive for COVID. That means he'll miss at least this week's game against the Packers and probably Week 10 (at New Orleans) as well. San Francisco then gets a Week 11 bye. We'll see when WR Deebo Samuel returns to the field. He has continued to miss practice this week with his hamstring injury. Trent Taylor and Richie James look next in line for WR targets. Taylor would be in play for deep PPR lineups if Samuel remains out vs. Green Bay.

49ers WR Brandon Aiyuk (hamstring) is inactive for today’s game against the Cardinals. With WR Deebo Samuel also out, Kendrick Bourne and Trent Taylor figure to operate as San Francisco’s top 2 WRs.

The 49ers have placed WR Deebo Samuel (foot) on IR. It's a bit surprising after Samuel was seemingly trending in the right direction -- and potentially even being ready for Week 1. We haven't heard of a setback, but Samuel is now out for at least the first 3 weeks. With WR Brandon Aiyuk (hamstring) questionable for Sunday's opener vs. Arizona, Kendrick Bourne and Trent Taylor figure to operate as San Francisco's top 2 WRs.

49ers WRs Deebo Samuel (foot) and Brandon Aiyuk (hamstring) missed practice on Wednesday. Fantasy owners shouldn't be counting on either guy to play against the Cardinals this weekend. Their absences would leave Kendrick Bourne and Trent Taylor as San Francisco's top 2 WRs. TE George Kittle should dominate targets.

Niners rookie WR Brandon Aiyuk left practice Sunday morning with a left hamstring injury, according to NBC Sports' Matt Maiocco. Injuries to Deebo Samuel and Jalen Hurd had left Aiyuk as the potential leader of the WR corps. We'll see how significant this issue proves to be. Yet another WR injury only increases opportunity for Kendrick Bourne and slot man Trent Taylor. Either guy is worth a look late in deep fantasy football drafts. Aiyuk remains a high-upside pick in the double-digit rounds, as long as this hammy injury doesn't prove to be too serious. Aiyuk reportedly finished the Sunday session watching from the sideline, which is obviously more encouraging than if he'd gone immediately in for treatment.

49ers WR Jalen Hurd is having a Monday morning MRI on "what's believed to be a major knee injury" suffered in Sunday practice, according to NFL Network's Mike Garafolo. The team reportedly fears that Hurd suffered an ACL tear. Such fears tend to be confirmed by testing. We'll keep an eye on this situation, but you should certainly stop drafting Hurd immediately. His absence would leave even more available for Brandon Aiyuk, as the Niners await Deebo Samuel's return to health. WRs Kendrick Bourne and Trent Taylor would also find more opportunity available. Aiyuk is a high-upside option for your fantasy bench. Taylor and Bourne would be late-draft flyers.

49ers WR Dante Pettis (groin) is not listed on the final injury report after putting in full practices on Thursday and Friday. WRs Trent Taylor (foot) and Jalen Hurd (back) are both out for this weekend’s opener against the Bucs. Marquise Goodwin is expected to serve as the #2 WR, with Kendrick Bourne, Deebo Samuel and Richie James filling spots 3 through 5.

49ers WR Dante Pettis is "having a rough camp," according to the Santa Rosa Press Democrat's Grant Cohn. Pettis was replaced in the starting lineup in Tuesday's practice by WR Kendrick Bourne. We're guessing that's not a permanent move, but it also sounds like San Francisco's WR pecking order remains extremely fluid at this point. It'll be a situation to monitor closely in preseason action.

49ers WR Marquise Goodwin (calf) is out for Sunday’s finale against the Rams. With WR Dante Pettis (knee) also out, San Francisco is down to Kendrick Bourne, Trent Taylor and Richie James. Bourne is the best fantasy bet but not more than a WR4. Look for TE George Kittle to lead the ‘Niners in targets.

49ers WRs Marquise Goodwin (personal) and Pierre Garcon (knee) are out for this weekend’s game in Seattle.Dante Pettis, Kendrick Bourne and Richie James will serve as San Francisco’s top 3 WRs.Pettis is the only fantasy consideration — and he’s just a WR4 flier.

49ers WR Pierre Garcon (knee) will miss Monday's contest against the Giants. He missed each practice during the week. With Garcon sidelined, San Francisco will primarily utilize Marquise Goodwin, Richie James, Dante Pettis and Kendrick Bourne at WR.

49ers WR Marquise Goodwin is considered questionable for Week 5 after suffering quad and hamstring injuries in Sunday's loss to the Chargers, according to insider Nick Wagoner. Goodwin battled through the injuries in that one, but we'll see what he's able to do in practice this week. With WR Dante Pettis (knee) out, the 'Niners could be down to WRs Pierre Garcon, Trent Taylor and Kendrick Bourne vs. the Cardinals this weekend.