The 49ers have ruled LB Dre Greenlaw (calf) out for Sunday's game against the Seahawks. Azeez Al-Shaair looks like his playing-time replacement. No other Niners LB behind Al-Shaair, Greenlaw and Fred Warner has played more than 28 snaps on the season.

49ers WR Brandon Aiyuk suffered a high-ankle sprain in Saturday's win over the Cardinals and will miss the finale vs. the Seahawks. It ends an impressive rookie campaign that saw Aiyuk average 6.6 catches, 83 yards and .6 TDs over his final 7 games. Kendrick Bourne and Richie James will close out the season as San Francisco's top 2 WRs.

Niners HC Kyle Shanahan confirmed Thursday that TE George Kittle will play against the Cardinals on Saturday. According to multiple reports, Shanahan said Kittle might be the healthiest player on the team and that he has looked good in practice. The TE might see some limitation to his playing time, but we wouldn't bet they'd return the star to action unless they expected him to help. Kittle jumps right back in among the top TE plays for Week 16.

The San Jose Mercury News' Cam Inman believes TE George Kittle (foot) is on track to return for Saturday's game against the Cardinals. Both GM John Lynch and team doctors have given Kittle the green light. “Yes, you have to have discretion and all those things, but we’ve been very thoughtful about this, and if he plays, it’s only because he’s ready to play,” Lynch said. “He’s eager to play and we want him to play.” It sure sounds like Kittle would be returning to something close to his regular role. There might be some risk of re-injury, but Kittle would also boast as much upside as any TE outside of maybe Travis Kelce. It's worth noting that Kittle posted a 15-183-1 line in his 1st game back from injury -- albeit a different injury -- earlier this season.

49ers RB Jeff Wilson isn't listed on the Week 16 injury report. He appeared to tweak a hamstring in last week's loss to the Cowboys but is evidently good to go for Saturday's game vs. the Cardinals. With RB Raheem Mostert out with his ankle injury, Wilson is set up for a heavy workload.

Niners HC Kyle Shanahan announced Tuesday that WR Deebo Samuel will miss the rest of the season with his hamstring injury. That clears the way for Brandon Aiyuk to remain the #1 WR over the next 2 weeks, with Kendrick Bourne and Richie James as #2 and #3.

49ers HC Kyle Shanahan said there's a chance TE George Kittle (foot) returns for Saturday's game against the Cardinals. "f he’s good, I plan on him playing," Shanahan said. Kittle has been sidelined since Week 8 and would carry elevated risk in his 1st game back. But he'd certainly make sense for a lot of fantasy teams considering how ugly the TE position has been this season. We'll monitor Kittle's status throughout the week.

The 49ers have designated QB Jimmy Garoppolo to return from IR. That doesn't necessarily mean he'll play again this season; it simply opens the 21-day practice window. With just 2 weeks remaining, that means the team could have Garoppolo practice the rest of the way without needing to decide on activating him. We wouldn't bet on Garoppolo taking the field in Week 16. C.J. Beathard appears in line to face the Cardinals on Saturday.

Update: Cam Inman reports that Garoppolo will practice but "won't play in games." With Nick Mullens set for elbow surgery, Beathard looks like the starter for the final 2 games.

NFL Network's Ian Rapoport reports that 49ers RB Raheem Mostert suffered another high-ankle sprain in Sunday's loss to the Cowboys and is "likely" done for the season. That leaves Jeff Wilson Jr. likely to lead the Week 16 backfield, assuming his own ankle issue doesn't get in the way. Tevin Coleman and Jerick McKinnon sit behind Wilson on the depth chart.

Update: Tom Pelissero reports that the team is placing Mostert on IR.

49ers RB Jeff Wilson appeared to injure his right hamstring late in the loss to Dallas. We’ll update his status when we learn more. Tevin Coleman and Jerick McKinnon are left as San Francisco’s healthy RBs.

49ers RB Raheem Mostert re-injured his left ankle in the 3rd quarter of Sunday's game against the Cowboys. We'll pass along an update when we get one, but it sure looks like Mostert's day is over.

Niners LB Fred Warner (neck, shoulder) and CB Emmanuel Moseley (hamstring) are active for today's game against the Cowboys. Starting outside CB Jason Verrett is a surprise inactive, though, after coming down with an illness. Verrett's absence improves the matchup for Cowboys WRs Michael Gallup and Amari Cooper, who spend most of their time outside.

NFL Network's Ian Rapoport reports that 49ers TE George Kittle (foot fracture) "appears ready to play" in Week 16 after returning to practice this week. But that doesn't necessarily mean Kittle will return. "A lot will go into that decision," a source told Rapoport. At 5-8, San Francisco enters Sunday 2 full games behind Arizona for the final playoff spot in the NFC. A Niners loss and Cardinals win today would eliminate San Francisco from playoff contention, as far as we can tell. That might also keep Kittle from getting back onto the field. We'll see about the TE's status over the coming week. As for QB Jimmy Garoppolo (high-ankle sprain), Rapoport reports he won't play in Week 16 and isn't expected to return for Week 17.

Niners LB Fred Warner (stinger) is questionable for Sunday's game against the Cowboys. He made it back to full practice participation Friday, though. We'll check Warner's status Sunday morning when the inactives come out. CB Emmanuel Moseley (hamstring) is questionable for the game as well. Like Warner, though, he progressed from 2 limited practices to a full Friday. Moseley missed the past 2 games but seems to be trending toward a return. Moseley has been a low-level IDP option most of the year.

49ers RB Raheem Mostert (ankle) put in a full practice on Friday and isn't listed on the final injury report. So he should be ready for his usual role vs. the Cowboys this weekend. Mostert has worked in a committee alongside RB Jeff Wilson the past 3 weeks, leading in carries 39 to 30 but trailing 8 to 7 in targets.

49ers WR Deebo Samuel (hamstring) is out for Sunday’s game against the Cowboys. That leaves Brandon Aiyuk as the #1 WR and a strong target bet. Kendrick Bourne figures to operate as the #2 WR but would be a desperation fantasy play.

49ers RB Raheem Mostert (ankle) returned to a limited practice on Thursday. It gives him a chance to play against the Cowboys this weekend. Check back tomorrow afternoon for another update on his status.

49ers RB Raheem Mostert (ankle) did not practice on Wednesday. We don't have any details on the ankle injury, but he's clearly in some danger of missing this weekend's game vs. Dallas. Mostert's absence would presumably make Jeff Wilson San Francisco's lead back, with Tevin Coleman and Jerick McKinnon candidates for bigger roles.

49ers TE George Kittle (foot) has been activated from IR. NBC Sports' Matt Maiocco reports that Kittle is not expected to play against the Cowboys this Sunday -- but a Week 16 return now looks plausible. We'll keep an eye on the situation, but Kittle is worth a stash if he was dropped in your league.

49ers RB Raheem Mostert came out of Sunday's loss to Washington with an ankle injury, HC Kyle Shanahan said. Mostert was getting additional testing done on Monday, and Shanny said he'd know more about Mostert's status on Wednesday. We'll keep an eye on the situation. Jeff Wilson would seemingly be in line to operate as San Francisco's lead back vs. Dallas this weekend if Mostert is out.