Bills RB Devin Singletary (hamstring) is inactive for today’s game against the Titans. He was reportedly a game-time decision, so the warmup must not have gone well. Singletary’s absence leaves Buffalo’s backfield to Frank Gore and T.J. Yeldon again.

The Bills racked up 254 yards and 3 TDs on the ground in Saturday's win at Chicago. RB Devin Singletary rushed 12 times for 106 yards and a TD. His score came from 33 yards out. RB James Cook carried 11 times for 99 yards and his own TD, which came from 27 yards out. QB Josh Allen contributed the other rushing score, among 6 carries for 41 yards.

Bills RBs totaled just 13 rushing attempts in Sunday's win over the Jets. Devin Singletary led with 8 carries for 39 yards. Rookie James Cook added 4 carries for just 6 yards. Nyheim Hines claimed the other, gaining 3 yards. The trio also combined for just 4 targets. Singletary led there as well, catching 1 of his 2 looks for 4 yards. Cook caught his long target for 9 yards. Hines caught his only opportunity for 4 yards. It'll be tough to like any of these RBs in the Week 15 matchup with the Dolphins.

The normally pass-favoring Bills leaned on the running game in Sunday's win over the Browns. RB Devin Singletary led the way, with 86 yards and the team's only rushing score on 18 carries. Rookie James Cook added 86 yards on 11 carries. Nyheim Hines barely factored in again, losing 8 yards on his lone carry and watching his lone target fall incomplete. Thanksgiving Day brings a Detroit defense that entered Sunday just 27th in Football Outsiders' run-defense DVOA.

Bills RB Devin Singletary chipped in 2 goal line TDs in Sunday’s loss to Minnesota. Singletary actually saw 4 total goal line carries — including 3 in the 1st quarter alone. It was a deviation from what we’ve seen this year, but perhaps Josh Allen’s injured elbow played a role. Singletary lost a close fumble and added only 1 catch (2 targets). Oddly, Buffalo also activated Duke Johnson, who mixed in for 2 carries behind James Cook (5 attempts). Nyheim Hines at least remained a total non-factor on offense with 1 touch. Singletary draws a favorable matchup with Cleveland in Week 11.

Bills RB Devin Singletary led the backfield with 8 carries (for just 24 yards) in Sunday's loss to the Jets and tied for 2nd on the team in targets (5). He caught 4 balls for 24 yards on a tough day for the passing offense. Rookie James Cook added 2 catches for 18 yards among 4 targets, plus a 4-15 rushing line. Nyheim Hines played just 3 offensive snaps and watched his lone target sail past him on a downfield route. Singletary dominated playing time, garnering 47 snaps to Cook's 14. We'd certainly bet on a playing-time increase for Hines as he gets more time in the offense.