Bills RB Devin Singletary (hamstring) is inactive for today’s game against the Titans. He was reportedly a game-time decision, so the warmup must not have gone well. Singletary’s absence leaves Buffalo’s backfield to Frank Gore and T.J. Yeldon again.

As expected, Devin Singletary led the Bills backfield in Thursday night's opener vs. the Rams. He played 59% of the offensive snaps and handled 8 carries and 2 targets. RB Zack Moss played a bigger role than we expected, registering a 38% snap rate, 6 carries and 6 targets. Rookie RB James Cook lost a fumble on his 1st touch of the night and ended up playing just 2 more snaps the rest of the way. This is shaping up as an ugly situation for fantasy football. Singletary is the best bet for now but is no more than a RB3 or flex. Moss is worth a bench spot in leagues of 12+ teams. Ditto for Cook, whose role still figures to grow throughout the season.

"The Bills’ running back corps has all the potential to devolve into a muddy three-person committee dependent on the situation and riding the hot hand," The Athletic's Joe Buscaglia writes. We know RBs Devin Singletary and James Cook will have a role in this backfield, but Buscaglia believes RB Zack Moss could be an "early-down threat to Singletary" and the goal-line back. That, of course, would put a major dent in Singletary's fantasy value. Buscaglia also says that Cooks' role "could be smaller than some expect."

The Athletic’s Joe Buscaglia writes that the Bills’ coaching staff “remains firmly behind” RB Devin Singletary “as an important piece to the [backfield] puzzle.” Buscaglia expects Singletary to remain the “lead back by playing time” over late-Round 2 pick James Cook. The veteran likely cemented his role with a strong end to 2021, rushing 102 times for 430 yards and 8 scores over his final 6 games (playoffs included). However, Cook’s arrival does make Singletary a virtual lock to fall shy of his 40 catches from 2021. Current projections have him slated for only 25 catches.

Beat writer Joe Buscagila of The Athletic believes the Bills “should” spend a “Day 2 or early Day 3 pick” on a RB. Buscagila points out that the current Bills staff has typically favored a 1-2 punch. Zack Moss took a step back after a promising rookie year. Devin Singletary, meanwhile, impressed with career highs in yards, TDs and receptions. He enters the offseason as Buffalo's clear lead back -- just note that he enters the final year of his rookie deal. GM Brandon Beane also spoke this offseason about adding more speed to the offense, and such a move could come in the form of a new RB. “I’m always looking for speed,” Beane said in January. “You’d love to have a (run after catch) guy that you can get the ball to and he can turn a five-yard pass into a 60-yard touchdown. We talked about speed here. You can never have enough of that. So we’ll continue to look for various ways.”

Bills RB Devin Singletary got the start in Saturday's preseason finale and played all 12 snaps on the 1st possession. RB Zack Moss ended up leading the backfield with 16 snaps with QB Josh Allen, though. Singletary played 15 and RB Matt Breida 7. Breida, interestingly, played 6 of those 7 snaps in the slot or split out wide. This is looking like at least a 2-man, and potentially a 3-man committee heading into Week 1.