The Cardinals placed RB Bam Knight on IR with the ankle injury suffered in Sunday's loss to the Texans. He's the third Arizona RB to be lost for the season, following James Conner and Trey Benson. The backfield is now down to Michael Carter and Emari Demercado. Carter dominated work in Houston, tallying 14 carries and four targets to Demercado's one carry and three targets. We're expecting Demercado to be a bit more involved the rest of the way, but Carter is the far superior fantasy bet. And he gets nice matchups the next two weeks vs. the Falcons (19th vs. RBs) and Bengals (32nd).

Cardinals RB Bam Knight suffered a "bad" ankle sprain in Sunday's loss to the Texans, according to ESPN's Adam Schefter. Knight is undergoing an MRI to get a better look at the damage. But he's "unlikely" to play vs. the Falcons this weekend, per Schefter. And it seems like there's a chance he misses the rest of the season. Knight's absence will leave Michael Carter as Arizona's lead back, with Emari Demercado in a change-of-pace, pass-catching role. Carter will be a viable RB3 or Flex in Week 16 fantasy lineups.

Cardinals TE Trey McBride posted a week-winning line in a Week 15 loss at Houston. On a 32.5% target share, the 26-year-old racked up 12 catches, 134 yards, and 2 TDs.

Cardinals RB Bam Knight hurt an ankle in the first quarter of Sunday's game vs. the Texans and was carted back to the locker room. He's officially questionable to return, but we'd be surprised if we saw him back out there today. Knight's absence leaves Arizona with RBs Michael Carter and Emari Demercado.

Update: Knight has been ruled out.

Cardinals RB Emari Demercado (ankle) is expected to play vs. the Texans today, according to ESPN's Adam Schefter. Demercado isn't a fantasy option but figures to steal some work, particularly on passing downs, from RBs Bam Knight and Michael Carter. Try to avoid Arizona's backfield in Week 15 fantasy lineups.

Cardinals WR Marvin Harrison Jr. (heel) is out for this weekend’s game vs. the Texans. He missed practice all week and has no timetable for return. Harrison’s absence will again mean alpha usage for WR Michael Wilson, who’s totaled an absurd 49 targets in three games without Harrison this season.

Cardinals WR Marvin Harrison Jr. (heel) remained sidelined for Wednesday's practice. Fantasy owners shouldn't be counting on him making it back for this weekend's game vs. the Texans. Harrison's absence would again mean a boatload of targets for WR Michael Wilson.

Cardinals RB Trey Benson (knee) will remain on IR, ending his 2025 season. The 23-year-old hasn’t played since Week 4.

The Arizona Cardinals were short-handed at WR in Week 14, but Michael Wilson stepped up again to deliver another phenomenal performance. Wilson caught 11 of his 16 targets for 142 yards and 2 TDs in the Cardinals' 45-17 loss. Wilson has now topped 21 PPR points in Arizona's last three games playing without supposed No. 1 WR Marvin Harrison Jr.

Cardinals WR Xavier Weaver (hamstring) is inactive for today’s game vs. the Rams. He joins WRs Marvin Harrison Jr. and Greg Dortch on the sidelines. WR Michael Wilson and TE Trey McBride should dominate Cardinals targets today.

Cardinals WR Greg Dortch (chest) has been placed on IR. He was already ruled out for Sunday's game vs. the Rams but will now miss at least another three games beyond that. WR Marvin Harrison Jr. (heel) is also out for Week 14, while WR Xavier Weaver (hamstring) is iffy after missing Friday's practice. Arizona elevated WRs Trent Sherfield and Jalen Brooks from the practice squad. They figure to join Michael Wilson and Andre Baccellia as the Cardinals' top four WRs against the Rams. Wilson and TE Trey McBride should dominate targets.

Arizona Cardinals WR Greg Dortch (chest) has been ruled out for Sunday's game against the Rams. Dortch suffered the injury in last week's loss to the Buccaneers and was unable to practice all week. The Cardinals will also be without No. 1 WR Marvin Harrison (heel), leaving them short-handed against the Rams. Michael Wilson and Trey McBride should see ample targets in this game. Wilson is now a fringe WR1 in our Week 14 WR rankings. Xavier Weaver (hamstring) didn't practice on Friday, leaving Andre Baccellia as the only other healthy WR on the roster. Tent Sherfield, Jalen Brooks, and Brittan Golden are options on Arizona's practice squad.

Cardinals RB Trey Benson (knee) won't play vs. the Rams this weekend, HC Jonathan Gannon said Friday. Gannon added that he's not sure if Benson will play again this season. Arizona needs to activate him from IR by December 10 in order for him to be eligible to return this year. Benson is worth keeping stashed until that date, but fantasy owners should not be banking on him contributing the rest of the way.

Cardinals QB Kyler Murray will not return this season, according to HC Jonathan Gannon. Gannon commented that Murray isn’t progressing as the team hoped and thus will not be available at all this season. Murray suffered a mid-foot injury in Week 5 and was placed on IR on November 5th. Jacoby Brissett will QB the team for the rest of the season.

Cardinals WR Marvin Harrison Jr. (heel) is out for Sunday's game vs. the Rams. He didn't practice all week, so this could be a multi-game absence. Harrison's absence once again leaves Michael Wilson as Arizona's top WR. He racked up 33 targets, 25 catches, and 303 yards in two games without Harrison in November. The Rams defense has played well this season but ranks just 19th in adjusted fantasy points allowed to WRs.

Cardinals WR Marvin Harrison Jr. (heel) missed practice again on Thursday. He's not looking like a good bet to play vs. the Rams this weekend, but we'll update his status again tomorrow. WR Greg Dortch (chest) has also missed the first two practices of the week, while WR Xavier Weaver was added to Thursday's injury report with a hamstring. WR Michael Wilson could be in for heavy volume on Sunday.

Cardinals WR Marvin Harrison Jr. (heel) did not practice on Wednesday. He tried to play through this heel injury last week but ultimately finished the game on the sidelines. Consider him uncertain for this weekend's meeting with the Rams. We'll update Harrison's status again tomorrow. His absence would turn WR Michael Wilson back into a strong fantasy starter.

Cardinals RB Trey Benson (knee) did not practice on Wednesday. He was limited last Wednesday before missing the final two practices of the week, so it sure looks like he suffered a setback. Don't bank on Benson playing vs. the Rams this weekend. His absence would again leave Bam Knight as Arizona's lead back, with Michael Carter and potentially Emari Demercado, who was limited on Wednesday, handling passing downs.

Cardinals HC Jonathan Gannon said Monday that QB Kyler Murray (foot) will not be designated to return from IR and practice this week. So he's out for Sunday's game vs. the Rams. QB Jacoby Brissett will make his eighth straight start in that one. He's finished as a top-12 fantasy QB in each of his first seven starts of the season. Sunday will be his toughest test yet against the Rams' sixth-ranked QB defense.

The Cardinals split time near-evenly between RBs in Sunday's loss at Tampa Bay. Michael Carter actually edged Bam Knight in total snaps, but Knight again led in touches and out-produced his teammate. Knight carried 11 times for 62 yards (5.6 yards per rush) to Carter's five carries for 17 yars (3.4). Carter beat Knight 6-3 in targets and 5-3 in receptions, but Knight still posted a nice 3-36-1 receiving line. Carter snagged 5 receptions for 47 yards.