ESPN's Adam Schefter reports that 49ers QB Jimmy Garoppolo is expected to miss at least the next 6 weeks with what has been deemed a high-ankle injury. The QB could remain out even longer if his injury winds up requiring surgery, according to Schefter. Garoppolo obviously doesn't belong on any redraft fantasy football rosters during this span. QB Nick Mullens is in play for deeper leagues, including 2-QB and superflex formats. We'll see, though, whether he can hold the job. C.J. Beathard relieved Mullens in the Week 4 loss to Philadelphia and then Garoppolo in the following week's loss to the Dolphins.

49ers QB Trey Lance (knee) did not practice on Monday. QB Jimmy Garoppolo (calf) was out there and looked good according to media members in attendance. At this point, bank on Garoppolo starting this weekend's game against the Colts. That'd be good news for WR Deebo Samuel.

49ers HC Kyle Shanahan said Tuesday that he expects QB Jimmy Garoppolo (calf) to be ready coming out of the Week 6 bye. “I mean, he’s doing good,” Shanahan said. “We’ll see when we get back [after the bye week]. I think he’ll be ready to go next week when we get back. That’s the plan. I know he’s doing a lot better now than he was last week.” Shanahan has consistently said that a healthy Garoppolo remains his starter. And, frankly, QB Trey Lance didn't play well enough in last week's loss to the Cardinals to change that.

49ers QB Jimmy Garoppolo (calf) is out for Sunday’s game against the Cardinals. He’ll get a Week 6 bye to heal up. But QB Trey Lance gets his 1st career start this weekend. He’s been shaky as a passer in the preseason and the 2nd half of last week’s game. But his high-end rushing ability gives him QB1 upside.

49ers QB Jimmy Garoppolo (calf) missed practice again on Thursday. It continues to look like QB Trey Lance will get his 1st career start vs. Arizona this weekend. We'll see if Garoppolo can get on the practice field tomorrow.

49ers QB Jimmy Garoppolo (calf) did not practice on Wednesday. QB Trey Lance took the 1st-team reps. HC Kyle Shanahan still believes Garoppolo has a shot to play vs. the Cardinals this weekend, but Lance seems like the odds-on favorite to be under center for that one.