49ers WR Brandon Aiyuk (COVID) is out for today’s game against the Rams. Deebo Samuel, Richie James and Kendrick Bourne should operate as San Francisco’s top 3 WRs.

49ers WR Brandon Aiyuk (shoulder) was limited in Wednesday's practice. He was seemingly close to playing last Thursday night, so we're tentatively expecting him back for this weekend's game vs. the Cardinals.

49ers WR Brandon Aiyuk (shoulder) is officially inactive for tonight's game vs. the Giants. He seemed relatively close to playing tonight, so we're tentatively expecting him back for Week 4. Aiyuk's absence should make San Francisco's offense even more concentrated, with RB Christian McCaffrey, WR Deebo Samuel, and TE George Kittle dominating touches.

The 49ers have downgraded WR Brandon Aiyuk to out for tonight's game against the Giants because of his shoulder injury. That should make Jauan Jennings the No. 2 WR for the upside matchup. Aiyuk (14) and Deebo Samuel (16) have accounted for 88.2% of WR targets for San Francisco through two weeks, with Jennings claiming the only other four. Jennings posted three games of 4+ receptions last year, though none came with Brock Purdy behind center. Jennings makes for a nice play in Thursday night DFS showdowns. He's too much of a longshot for most season-long redraft formats, though. Seventh-round rookie Ronnie Bell has been the No. 4 WR in playing time so far and matched Jennings in snaps in Week 2. He has yet to see a target, though.

The 49ers list WR Brandon Aiyuk (shoulder) as questionable for Thursday night's game against the Giants. ESPN's Nick Wagoner reports that HC Kyle Shanahan "indicated" Aiyuk will be a game-time decision. Fortunately, it's the first game of the week. So we'll know more before you're setting your Week 3 lineups.

49ers WR Brandon Aiyuk (shoulder) will be a game-time decision for Thursday night's meeting with the Giants, HC Kyle Shanahan said Tuesday. Aiyuk was limited in Tuesday's practice. We'll continue to look for updates on his status, but it seems like he'll come with elevated risk in Week 3 fantasy lineups if he does suit up on Thursday night.