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Buffalo
2:11pm EST 11/29/20

49ers WR Brandon Aiyuk (COVID) is out for today’s game against the Rams. Deebo Samuel, Richie James and Kendrick Bourne should operate as San Francisco’s top 3 WRs.

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Addressing 49ers WR Brandon Aiyuk's usage in the opener, insider Matt Maiocco wrote that Aiyuk "tailed off dramatically" in training camp and is "still learning how to be a pro." If that's the case, it went completely unreported. "Kyle Shanahan, clearly, favors some of the other WRs right now," Maiocco added. Aiyuk ended up finishing 2nd among 49ers WRs with 15 pass routes in Week 1 -- but that was just 1 more than Trent Sherfield and 4 more than Mohamed Sanu. Easily a top 2 talent on the roster, Aiyuk should eventually return to a full-time role. But he can't be trusted in fantasy lineups until we see it happen.

49ers WR Brandon Aiyuk finished without a single target in Sunday's opener vs. the Lions. We're still waiting for final snap counts but believe Aiyuk was 3rd or 4th among 49ers WRs in snaps. HC Kyle Shanahan said after the win that Aiyuk's late-August hamstring injury played a part in the reduced role today. We'll keep an eye on this situation, but Aiyuk will be impossible to trust in Week 2 fantasy lineups.

49ers WR Brandon Aiyuk (hamstring) put in a full week of practice and isn't listed on the final injury report. He should have his way with the Lions CBs on Sunday. But overall pass volume from San Francisco is a concern.

49ers WR Brandon Aiyuk (hamstring) was a full participant in Wednesday's practice. It's confirmation that he's good to go for Sunday's plus matchup vs. the Lions.

49ers WR Brandon Aiyuk (hamstring) returned to practice on Monday. That seemingly puts him on track to play in this weekend's opener vs. the Lions. We'll get San Francisco's 1st official practice report on Wednesday.

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