Niners HC Kyle Shanahan hopes to have WR Deebo Samuel available for the regular-season opener, but says it's too early to tell, according to the team website. "I think we're hoping for Week 1. Not counting on it, but I think that's kind of the area that these injuries usually heal by. But a lot of that has to do with: are you ready to play? Has it fully healed by that time? Are you in football shape?" Shanahan acknowledged that it'll be tough to know how ready Samuel might be before he actually returns to the field. We'll certainly keep an eye on the 2nd-year wideout's status as the regular season draws nearer. In the meantime, his uncertainty adds upside to the late-round price tags on WRs Brandon Aiyuk and Jalen Hurd.

49ers WR Deebo Samuel played 19 snaps in Sunday's preseason game vs. the Chargers, finishing with 1 catch on 2 targets for 9 yards. He reportedly got an MRI for a tight glute last week -- but it's clearly not an issue at this point.

Niners WR Deebo Samuel left Friday's practice early and is getting an MRI. "He had a tight glute today, so he pulled himself out of practice," HC Kyle Shanahan said afterward, per 49erswebzone.com. We'll see whether there's anything to worry about here.

49ers WR Deebo Samuel has had a healthy offseason and is in "great shape," according to The Athletic's David Lombardi. "It’s been the talk of camp around the 49ers’ building," Lombardi adds. "He’s lighter, faster and has already expressed eagerness to run more deep routes." Durability has been a problem for Samuel dating back to his South Carolina days. But he's been productive when healthy through 2 NFL seasons. Barring injury, he'll likely finish closer in fantasy points to WR Brandon Aiyuk than current ADP suggests.

Niners HC Kyle Shanahan announced Tuesday that WR Deebo Samuel will miss the rest of the season with his hamstring injury. That clears the way for Brandon Aiyuk to remain the #1 WR over the next 2 weeks, with Kendrick Bourne and Richie James as #2 and #3.

49ers WR Deebo Samuel (hamstring) is out for Sunday’s game against the Cowboys. That leaves Brandon Aiyuk as the #1 WR and a strong target bet. Kendrick Bourne figures to operate as the #2 WR but would be a desperation fantasy play.