49ers GM John Lynch suggested in a Wednesday radio interview that RB Jerick McKinnon suffered another setback in his return from last year's torn ACL. "It’s a real bummer," Lynch said. "He keeps getting to the final step. We did it a month ago and he kinda regressed and yesterday we had a similar situation." McKinnon is basically a full year removed from his injury and still can't string together multiple practices without trouble. He won't be an early-season fantasy factor and, at this point, is only worth rostering in the deepest of redraft leagues.

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The 49ers have opted to place RB Jerick McKinnon (knee) on season-ending injured reserve, according to NFL Network's Ian Rapoport. That leaves Tevin Coleman and Matt Breida as the team's clear top 2 RBs. Raheem Mostert is 3rd on the depth chart.

The 49ers are placing RB Jerick McKinnon (knee) on IR, according to NFL Network's Ian Rapoport. It's unclear if McKinnon has a shot to play the 2nd half of the season as a designated-to-return player. Rapoport hears that McKinnon might have had another procedure on that troublesome knee. We'll keep an eye on him, but McKinnon isn't worth stashing in fantasy leagues that don't have an IR spot. RBs Tevin Coleman (5.09) and Matt Breida (8.02) are both worth considering at ADP.

49ers RB Jerick McKinnon (knee) returned to practice on Tuesday. He made it just a couple of days in early August before experiencing discomfort in his surgically repaired knee. We'll see if he's truly good to go now. But he's the clear #3 on the depth chart at this point behind Tevin Coleman and Matt Breida. McKinnon is no more than a late-round flier in fantasy drafts.

Matt Barrows of The Athletic reports that HC Kyle Shanahan named RB Jerick McKinnon among "a slew" of Niners who are "on tap to return to practice this week." That'd obviously be great news for a player who opened training camp on the PUP and then suffered a setback in his repaired knee shortly after returning. McKinnon will need to prove his knee can hold up this time before he's worth much fantasy football draft attention. We'd still much rather take Matt Breida. Tevin Coleman is OK at cost.

Matt Maiocco of NBC Sports Bay Area reports that 49ers RB Jerick McKinnon's right knee "was not feeling good after working the past 2 days" and that "he'll be shut down for a while." That doesn't sound good for a guy who missed the whole set of offseason workouts and the start of camp in his return from last year's ACL tear. McKinnon figures to at least open the season behind Tevin Coleman and Matt Breida. He might also be in danger of starting the year on IR. (San Francisco can't put him on the regular-season PUP after activating him from the camp PUP this week.) McKinnon's situation has produced some movement in our RB rankings.

Update: HC Kyle Shanahan said after Thursday's practice that McKinnon will receive a platelet rich plasma injection in his troublesome knee and "could" be back in 2 weeks. The goal, Shanny said, is for McKinnon to be ready for Week 1. We'll see.

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