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NFL Network's Ian Rapoport reports that 49ers RB Raheem Mostert suffered another high-ankle sprain in Sunday's loss to the Cowboys and is "likely" done for the season. That leaves Jeff Wilson Jr. likely to lead the Week 16 backfield, assuming his own ankle issue doesn't get in the way. Tevin Coleman and Jerick McKinnon sit behind Wilson on the depth chart.

Update: Tom Pelissero reports that the team is placing Mostert on IR.

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49ers RB Raheem Mostert announced on social media that he'll undergo season-ending knee surgery after consulting with multiple doctors. So, if you weren't already planning to, you can safely drop Mostert from all redraft rosters. San Francisco is left with Elijah Mitchell, JaMycal Hasty and Trey Sermon at RB. All 3 figure to be active for Week 2. It's also worth noting that RB Jeff Wilson (knee) is eligible to come off the PUP list in Week 7. You can see where all of those guys sit in our updated Rest-of-Season Rankings.

Niners RB Raheem Mostert has chipped cartilage in the knee he injured Sunday. ESPN’s Nick Wagoner reports that he’ll land on IR and is expected to miss 8 weeks. Elijah Mitchell took control of the backfield after Mostert left in Detroit, with JaMycal Hasty involved as well. We’d bet on Trey Sermon being active at Philly in Week 2. We’ll see about the workload split. Obviously, we have to assume that Mitchell will lead the way again — barring reports to the contrary.

49ers HC Kyle Shanahan said after today's win over the Lions that RB Raheem Mostert is not dealing with an ACL injury. Shanahan didn’t have any other information. We should learn more tomorrow.

49ers RB Raheem Mostert is questionable to return to Sunday's game against the Lions with a knee injury. We'll pass along an update when we get one.

49ers RB Raheem Mostert got the start in Sunday's preseason finale and played all 10 snaps on the 1st possession. RB Trey Sermon then played all 14 snaps on the 2nd possession. Those 2 will open the season sharing backfield work. The exact split between them remains uncertain.

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