49ers WR Ricky Pearsall (ankle, knee) is out for Monday night's game vs. the Colts. He didn't practice all week and could certainly miss multiple games after aggravating his PCL injury last week. Pearsall's absence boosts the target projections on WR Jauan Jennings and TE George Kittle.

Commanders QB Marcus Mariota injured his right (throwing) hand in the third quarter of Saturday's game vs. the Eagles and did not return. He was also checked for a concussion but was cleared. QB Josh Johnson replaced Mariota, completing 5 of 9 passes for 43 yards and an INT. We'll look for further updates on Mariota's injury. Washington already said QB Jayden Daniels won't play again this season, so we could be looking at a Johnson-led offense for the final two weeks of the season. That'd be a big downgrade for the pass catchers.

Packers WR Dontayvion Wicks (ankle) is active for today’s matchup against Chicago. With Christian Watson also active, Wicks isn’t a recommended fantasy starter.

Packers RB Josh Jacobs (knee, ankle) is active for today’s game against Chicago. Jacobs turned 22 touches into 92 yards and a score in a Week 14 win over the Bears. While there’s a chance Green Bay limits his workload on a short week, the veteran remains an RB1.

Bears RB D’Andre Swift (groin) is active for today’s matchup with Green Bay. Swift was added to the injury report on Wednesday (limited), although he put in another limited session on Thursday. Expect Chicago to continue leaning run, especially with Rome Odunze and Luther Burden sidelined. Swift – with 16+ touches in three straight – remains an RB2.

Packers WR Christian Watson (shoulder, chest) is active for today’s game against Chicago. No surprise there, as Watson put in two limited practices to close out the week. He hits our Week 16 PPR WR rankings as a top-30 option.

Dolphins LB Jordyn Brooks is officially questionable for Sunday's game against the Bengals after foot and knee injuries limited him to just one limited practice this week. But Brooks told reporters after Friday's practice that he'll play this week, according to multiple reports.

The Panthers have ruled LB Trevin Wallace out for Sunday's game against the Buccaneers with a shoulder injury. Wallace followed a full Wednesday practice with limited work Thursday and Friday, giving the appearance of a midweek injury. But HC Dave Canales indicated after Friday's practice that Wallace had aggravated a previous shoulder injury in Sunday's loss to the Saints.

Bears RB D'Andre Swift (groin) is expected to play vs. the Packers tonight, according to ESPN's Jeremy Fowler. Swift is listed as questionable after being limited in the final two practices of the week. It adds some risk to his Week 16 profile, but we're ultimately expecting Swift to continue splitting backfield work with RB Kyle Monangai.

The Bears on Friday activated LB Tremaine Edmunds from IR. He's officially questionable for today's game against the Packers, but that move suggests he's likely to return to the lineup. We'll confirm his status once the inactives are announced 90 minutes before kickoff. Edmunds presents some risk in his first game back from a groin strain, but the upside makes him worth getting into most IDP lineups.

Rams HC Sean McVay said Friday that WR Davante Adams (hamstring) "most likely" won't play vs. the Falcons in Week 17. It's not surprising that Adams will miss multiple games with his hamstring injury. He could also miss Week 18, but we'll keep you updated on his status. The Rams went heavy on '13' personnel with Adams out in Seattle on Thursday night, with TEs Colby Parkinson and Terrance Ferguson tying for second on the team in pass routes, behind only WR Puka Nacua.

Raiders QB Geno Smith (shoulder, back) put in a full week of practice and is off the final injury report. He’ll start Sunday’s game vs. the Texans but is not a recommended play in any fantasy format. Vegas is implied for a pathetic 11.75 points.

Texans RB Woody Marks (ankle) is listed as questionable for this weekend’s game vs. the Raiders. He only got in a limited practice on Friday. RB Nick Chubb (ribs) is also listed as questionable but practiced all week, including full workouts on Thursday and Friday. We’ll look for further updates on this backfield but won’t get Houston’s inactives until a little before 3 pm ET on Sunday.

Broncos RB R.J. Harvey (ribs) put in a full week of practice and is off the final injury report for Sunday’s game vs. the Jaguars. He’ll be ready for lead-back duties in that one. Harvey ranks fifth among RBs in PPR points over the last three weeks and is a strong Week 16 start.

Cardinals WR Marvin Harrison Jr. (heel) is listed as questionable for Sunday’s game vs. the Falcons. He was limited in practice all week. Harrison said Friday that he's "good enough to go" this weekend, which doesn’t inspire a ton of confidence. It’s safe to assume he won’t be at 100% if he plays against Atlanta, leaving him as a risk/reward WR3. Harrison’s return would be bad news for WR Michael Wilson, though. Harrison out-targeted Wilson seven to three through the first three quarters of Week 13 (Harrison’s last game).

Jets TE Mason Taylor (neck) is out for Sunday’s game vs. the Saints. Jeremy Ruckert gets another game as lead TE but isn’t a fantasy option after catching two balls for 13 yards last week.

Bengals WR Tee Higgins (concussion) is listed as questionable for Sunday’s game vs. the Dolphins. He practiced all week, including a full workout on Friday, so he’s seemingly trending toward being cleared for this one. We’ll keep you updated on Higgins’ progress and get Cincinnati’s inactives around 11:30 am ET on Sunday. He’ll be a virtual must-start if he plays.

Ravens WR Rashod Bateman (ankle) is off the final injury report and will play vs. the Patriots on Sunday night. Bateman should step back in as Baltimore’s No. 2 WR after missing Week 15 but isn’t a viable fantasy play outside of one-game daily contests. He’s topped 24 receiving yards in just two of 11 games this season.

Chargers WR Quentin Johnston (groin) is listed as questionable for this weekend’s game vs. the Cowboys. He got in three limited practices, so we’re expecting him to play. But Johnston, who hasn’t topped 53 yards in a game since Week 4, is not a recommended fantasy start.

Chiefs WR Rashee Rice (concussion) is out for Sunday’s game vs. the Titans. He didn’t practice all week after reporting symptoms sometime after last weekend’s loss to the Chargers. Rice should have a good chance to make it back for Week 17, but we’ll track his progress next week. WR Tyquan Thornton (concussion) has also been ruled out for the Titans game, leaving Xavier Worthy, Marquise Brown, and JuJu Smith-Schuster as the likely top three WRs in this Gardner Minshew-led offense.