Niners rookie DE Nick Bosa left Wednesday's practice with a sprained right ankle, according to NFL Network's Ian Rapoport. That figures to keep him out for at least the 1st preseason game. We'll see what the timetable looks like beyond that.

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Niners DE Nick Bosa (ankle) is active for today's game against the Bengals. He had some soreness in his previously sprained ankle coming out of Week 1 and got some rest from practice during the week. But Bosa also graded out tops among all edge players in Pro Football Focus' pass-rushing productivity in Week 1. He's worth the risk against a Bengals offense that looks weak in pass protection.

Niners rookie DE Nick Bosa is questionable for Sunday's game at Cincinnati. Bosa came away from Week 1 with some soreness in his previously sprained ankle, GM John Lynch said during a radio interview Friday. Bosa sat out Wednesday's and Thursday's practices before returning to limited participation Friday. Lynch said Bosa was progressing well. We'll see if he's ready to go. There will be some re-injury risk even if he plays but also enticing sack upside.

Niners DE Nick Bosa is active for today's opener against the Buccaneers. He only recently returned from a sprained ankle that kept him out for the preseason, though, and shouldn't be in IDP lineups.

Niners GM John Lynch struck an optimistic tone in talking about rookie DE Nick Bosa on KNBR radio Friday. "He's come along really well," Lynch said, referring to Bosa working back from his ankle sprain. But Lynch added that the top pick remains uncertain for the start of the year. "Week 1, that's, I don't know, 50-50," he said. "But it's going to be touch and go as to whether he makes it." If Bosa does manage to make the active roster for that game, it seems unlikely the rookie -- who missed all of the preseason -- would play a big role. We'll see how soon Bosa can get back to full strength and push for starter-level playing time. The Bay Area News Group reported that Bosa was out of his walking boot and working on conditioning with trainers at Wednesday's practice.

The 49ers will practice without top pick DE Nick Bosa for "the next few weeks" (according to NBC Bay Area's Matt Maiocco) because of a Grade 1 hamstring strain. That's the lowest level on the scale, so it's not a serious situation in May. But Bosa's hamstring will bear watching come training camp. His brother missed the 1st 4 games of his 2016 rookie campaign with hamstring trouble. Nick Bosa, of course, sat out nearly all of his final Ohio State season following sports hernia surgery.

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