Bills RB Devin Singletary (hamstring) remained sidelined on Wednesday. At this point, we're not expecting him to play against the Patriots this weekend. With the rookie out last week, Frank Gore played 63% of the offensive snaps, carried 14 times and saw 2 targets. T.J. Yeldon registered a 37% snap rate, 8 carries and 3 targets.

Bills RB Devin Singletary set a season high in total yards for the 2nd straight game in Sunday's win over the Ravens. Singletary gained 49 yards on 11 carries and caught 4 of 5 targets for 47 yards. Those 96 total yards edged his 91 total yards from the Week 3 loss at Miami. Neither amounted to a big fantasy day (though he added a TD against the Dolphins), but the strong yardage signals what's available to him as Buffalo's clear lead back. Singletary figures to reside in RB3 territory of our rankings most weeks, but he'll be a solid option in that range with clear upside when he gets some TD luck. Zack Moss handled the other 3 RB rushes for the Bills at Baltimore, with James Cook drawing the group's only other target.

Bills RB Devin Singletary set a career-high with 9 catches in Week 3 vs. Miami. He scored early in the game on a 4th-down pass where the Dolphins defense left him completely unmarked. Those contributions were key for fantasy, as the contract-year rusher added only 13 yards on 9 carries. Sunday’s game was played in extreme heat, so it’s quite impressive that Singletary handled 67 snaps (73%). Zack Moss, meanwhile, played only 16 snaps (5 touches). Singletary should remain a viable FLEX for the road ahead.

As expected, Devin Singletary led the Bills backfield in Thursday night's opener vs. the Rams. He played 59% of the offensive snaps and handled 8 carries and 2 targets. RB Zack Moss played a bigger role than we expected, registering a 38% snap rate, 6 carries and 6 targets. Rookie RB James Cook lost a fumble on his 1st touch of the night and ended up playing just 2 more snaps the rest of the way. This is shaping up as an ugly situation for fantasy football. Singletary is the best bet for now but is no more than a RB3 or flex. Moss is worth a bench spot in leagues of 12+ teams. Ditto for Cook, whose role still figures to grow throughout the season.

"The Bills’ running back corps has all the potential to devolve into a muddy three-person committee dependent on the situation and riding the hot hand," The Athletic's Joe Buscaglia writes. We know RBs Devin Singletary and James Cook will have a role in this backfield, but Buscaglia believes RB Zack Moss could be an "early-down threat to Singletary" and the goal-line back. That, of course, would put a major dent in Singletary's fantasy value. Buscaglia also says that Cooks' role "could be smaller than some expect."

The Athletic’s Joe Buscaglia writes that the Bills’ coaching staff “remains firmly behind” RB Devin Singletary “as an important piece to the [backfield] puzzle.” Buscaglia expects Singletary to remain the “lead back by playing time” over late-Round 2 pick James Cook. The veteran likely cemented his role with a strong end to 2021, rushing 102 times for 430 yards and 8 scores over his final 6 games (playoffs included). However, Cook’s arrival does make Singletary a virtual lock to fall shy of his 40 catches from 2021. Current projections have him slated for only 25 catches.