The 49ers have ruled DE DeForest Buckner out for Thursday night's game against the Cardinals because of a foot injury. Coaches had expressed optimism earlier in the week that Buckner would be able to play, so the 10-day layoff before a Week 6 meeting with the Bills should put the rookie in good shape to return.

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Colts DT DeForest Buckner (ankle) is active for today's game against the Bills. He's probably somewhere short of full strength, but his presence makes a big difference for the Colts' defense vs. both the run and pass.

Colts DT DeForest Buckner is questionable for Saturday's playoff opener against the Bills with an ankle injury. He has been listed with the same issue since Thursday of Week 15 but has yet to miss a game. Buckner followed the same practice participation this week as last -- out-out-limited -- but he finished last week with no injury designation. So it's possible the ankle is a bit worse this time around. Any limitation to Indy's best defensive lineman can obviously only help the Bills. We'll check his status when the inactives come out late Saturday morning.

Colts DT DeForest Buckner is active for today's game against the Texans. He hurt an ankle in Thursday's practice and then missed Friday's workout. That adds risk to using him in IDP lineups today, but Buckner remains a high-upside option.

The Colts on Wednesday placed DT DeForest Buckner on the COVID list. That puts him out for at least 10 days, according to NFL rules. So Buckner will miss this week's game against the Titans. We'll see about his status for Week 13. Indy DL Denico Autry also remains on the COVID list after missing last week's game. HC Frank Reich gave no update on Autry's status Wednesday. We'll see whether he can make it back to the active roster for the Tennessee game.

The 49ers on Monday traded DT DeForest Buckner to the Colts for a 1st-round pick. According to NFL Network's Ian Rapoport, Indianapolis is also extending Buckner's contract at a $21 million-per-year average salary. The move obviously sets up Buckner as a keystone in what should be an improving Colts offense. We'll see how losing Buckner affects San Francisco's top-shelf defense.

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