Broncos RB R.J. Harvey suffered a rib injury late in Sunday's win over the Packers and did not return. We'll look for updates on his status for Week 16 and beyond. With RB J.K. Dobbins on IR, Harvey's absence would leave Denver's backfield to Jaleel McLaughlin and Tyler Badie.

Rams WR Davante Adams hurt his hamstring injury running a deep route in the fourth quarter of Sunday's game vs. the Lions and did not return. This is presumably the same hamstring that had Adams listed as questionable coming into this one. We'll look for updates on his status, but consider him unlikely to be ready for Thursday night's game vs. the Seahawks.

Chiefs QB Patrick Mahomes tore his left ACL in the second half of Sunday's loss to the Chargers. That will obviously end his season. We'll see about the return timeline once doctors assess and address the full damage.

Cowboys TE Jake Ferguson (calf) is active for tonight’s game vs. the Vikings. He seemingly hurt his calf on Wednesday, did not practice on Thursday, but was able to return to a limited practice on Friday. That adds some risk to Ferguson’s Week 15 fantasy profile, but he’s available if you were waiting on him.

Saints WR Devaughn Vele is questionable to return to Sunday's game vs. the Panthers due to a shoulder injury. He led New Orleans with six targets, five catches, and 69 receiving yards before exiting late in the third quarter. We'll update his status when we know more.

Packers WR Christian Watson suffered an apparent left shoulder injury on a diving attempt for a deep ball in the third quarter of Sunday's game vs. the Broncos. Watson was in obvious pain and took a few minutes to get off the field. We'll keep you updated on Watson's status.

Update: Watson has been ruled out with a chest injury.

Broncos WR Marvin Mims left Sunday's game vs. the Packers with a stinger. He was also evaluated for a concussion but was cleared, according to the CBS broadcast. We'll update Mims' status when we know more. Denver is already without WR Pat Bryant (hamstring) today.

Update: Mims returned for the second half.

Last week, Shedeur Sanders had his signature breakout performance, accounting for 393 total yards and 4 TDs against the Titans and being named the Browns' starter for the remainder of the season. But Sanders plummeted back to Earth against Chicago's opportunistic defense in Week 15. Sanders completed 18 of 35 attempts for 177 yards, 0 TDs, and 3 INTs in Cleveland's 31-3 loss.

Saints RB Devin Neal injured his hamstring in the second quarter of Sunday's game vs. the Panthers and is questionable to return. His absence leaves Audric Estime as New Orleans' likely lead back. We'll update Neal's status when we know more.

Update: Neal has been ruled out.

Eagles QB Jalen Hurts threw just 15 passes in Sunday's beatdown of the Raiders. But he proved much more efficient than in recent weeks. Hurts completed 12 of those throws (80%) for 175 yards (11.7 yards per attempt) and 3 TDs. He added 39 rushing yards on seven carries.

Eagles RB Saquon Barkley rushed for 78 yards and a TD in Sunday's lopsided win over the Raiders. His 22 carries marked the second straight game of 20+ and fourth 20+ carry outing among six games since the team's bye. Barkley added 14 yards on 2 receptions among three targets, ranking second on the team in that last category on a day that found Jalen Hurts attempting only 15 passes.

Raiders TE Brock Bowers led the team in targets, receptions, and receiving yards in Sunday's loss to the Eagles. But that produced just a 6-28-0 receiving line on eight looks. QB Kenny Pickett threw for a mere 64 yards on 15-of-25 passing in place of the injured Geno Smith. RB Ashton Jeanty was the only other Raider to catch more than two passes.

Niners WR Ricky Pearsall limped off the field in the first quarter after a hip-drop tackle by Titans S Kevin Winston on his first reception. He was pretty clearly favoring his left knee but remained on the sideline. We'll see about his status as the game progresses. It's at least the opposite knee from the one in which he suffered his early-season PCL injury.

Update: Pearsall returned before the end of the quarter.

Chiefs QB Patrick Mahomes injured his left knee in the fourth quarter of Sunday's game vs. the Chargers. The knee hyperextended as he was scrambling away from pressure. Mahomes was in obvious pain but was able to limp off over his own power. We'll update Mahomes' status when we know more. QB Gardner Minshew is in for the Chiefs.

Bengals RB Samaje Perine hurt his right leg in the fourth quarter of Sunday's game vs. the Ravens. He was in obvious pain and could put no weight on the leg. We'll update Perine's status when we know more. His absence turns RB Chase Brown back into a workhorse.

Update: Perine returned on Cincinnati's next possession.

Bears WR Luther Burden injured his left ankle in the second half of Sunday's game vs. the Browns and is questionable to return. Don't expect to see him back out there with Chicago nursing a big lead. We'll keep you updated on the rookie's status. The Bears already lost WR Rome Odunze before kickoff today after he aggravated his foot injury.

Jaguars RB Bhayshul Tuten suffered a finger injury in the second half of Sunday's game vs. the Jets and is questionable to return. We'll update the rookie's status when we know more.

Update: Tuten has been ruled out.

49ers RB Christian McCaffrey (back) is active for today’s game vs. the Titans. He was added to the injury report as questionable on Saturday, but ESPN’s Adam Schefter reported a short time later that McCaffrey would be “good to go” for this one. We haven’t heard anything about his snaps or touches being limited today. McCaffrey remains a must-start.

Rams WR Davante Adams (hamstring) is active for today’s game vs. the Lions. He only got in a limited practice on Friday, but HC Sean McVay said throughout the week that Adams would be fine for this one. Keep him locked into fantasy lineups.

Packers RB Josh Jacobs (knee) is active for today’s game vs. the Broncos. He dealt with swelling in his knee throughout the week and only got in a limited practice on Friday. There’s certainly a chance that Green Bay limits Jacobs’ workload at least a bit today. We’ve factored that into his projections, but Jacobs still checks in 13th in the Week 15 RB rankings. RB Emanuel Wilson (illness) is also active today.